The neuropsychological profile of children with basal ganglia encephalitis

a case series

Chiara Pawela, Ruth K. Brunsdon*, Tracey A. Williams, Melanie Porter, Russell C. Dale, Shekeeb S. Mohammad

*Corresponding author for this work

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Inflammatory basal ganglia encephalitis (BGE) is a rare but distinct entity of putative autoimmune aetiology, with specific basal ganglia inflammation and acute movement disorders. Unlike most brain injuries, BGE is a radiologically pure basal ganglia syndrome. The current study systematically describes the neuropsychological outcomes of four paediatric cases of BGE, and thus the neuropsychological outcomes of focal basal ganglia insult in childhood. Although all patients made significant motor recoveries, all four cases displayed executive dysfunction, fine motor difficulties, and anxiety. Three out of four cases displayed attention deficits. The case who received intravenous immunoglobulin (IVIg) treatment and steroids during the acute phase of the disease had the best cognitive outcome. These findings highlight the need for detailed neuropsychological assessment and long-term follow-up.

Original languageEnglish
Pages (from-to)445-448
Number of pages4
JournalDevelopmental Medicine and Child Neurology
Volume59
Issue number4
DOIs
Publication statusPublished - Apr 2017

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