The neuropsychology of delusions

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Abstract

Work in the field of cognitive neuropsychiatry over the past 20 years has made it plain that various forms of delusional belief are scientifically understandable in the sense that plausible neuropsychological explanations of their nature and genesis have been formulated. A two-factor theory of delusional belief has emerged from this work. According to this theory, explaining the presence of a delusion requires (a) the presence a neuropsychological impairment that initially prompts the delusional belief and (b) the presence of a second neuropsychological impairment that interferes with processes of belief evaluation that would otherwise cause the delusional belief to be rejected. A very similar account of delusion has recently emerged from research on hypothesis evaluation using the associative-learning paradigm with healthy control subjects and people with psychosis. Neuroimaging studies in this context suggest that the region of the brain specifically involved in hypothesis evaluation (and therefore, according to the two-factor theory, impaired in people with delusions) is the right lateral prefrontal cortex.

LanguageEnglish
Title of host publicationThe year in cognitive neuroscience 2010
EditorsAlan Kingstone, Michael B. Miller
Place of PublicationBoston, Mass.
PublisherWiley-Blackwell, Wiley
Pages16-26
Number of pages11
Volume1191
ISBN (Print)9781573317900
DOIs
Publication statusPublished - Mar 2010

Publication series

NameAnnals of the New York Academy of Sciences
Volume1191
ISSN (Print)00778923
ISSN (Electronic)17496632

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Neuroimaging
Neuropsychology
Delusions
Brain
Neuropsychiatry
Prefrontal Cortex
Psychotic Disorders
Healthy Volunteers
Learning
Research

Cite this

Coltheart, M. (2010). The neuropsychology of delusions. In A. Kingstone, & M. B. Miller (Eds.), The year in cognitive neuroscience 2010 (Vol. 1191, pp. 16-26). (Annals of the New York Academy of Sciences; Vol. 1191). Boston, Mass.: Wiley-Blackwell, Wiley. https://doi.org/10.1111/j.1749-6632.2010.05496.x
Coltheart, Max. / The neuropsychology of delusions. The year in cognitive neuroscience 2010. editor / Alan Kingstone ; Michael B. Miller. Vol. 1191 Boston, Mass. : Wiley-Blackwell, Wiley, 2010. pp. 16-26 (Annals of the New York Academy of Sciences).
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Coltheart, M 2010, The neuropsychology of delusions. in A Kingstone & MB Miller (eds), The year in cognitive neuroscience 2010. vol. 1191, Annals of the New York Academy of Sciences, vol. 1191, Wiley-Blackwell, Wiley, Boston, Mass., pp. 16-26. https://doi.org/10.1111/j.1749-6632.2010.05496.x

The neuropsychology of delusions. / Coltheart, Max.

The year in cognitive neuroscience 2010. ed. / Alan Kingstone; Michael B. Miller. Vol. 1191 Boston, Mass. : Wiley-Blackwell, Wiley, 2010. p. 16-26 (Annals of the New York Academy of Sciences; Vol. 1191).

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

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Coltheart M. The neuropsychology of delusions. In Kingstone A, Miller MB, editors, The year in cognitive neuroscience 2010. Vol. 1191. Boston, Mass.: Wiley-Blackwell, Wiley. 2010. p. 16-26. (Annals of the New York Academy of Sciences). https://doi.org/10.1111/j.1749-6632.2010.05496.x