The one hundred percent hypothesis

Glutamate or gaba in synapses on sympathetic preganglionic neurons

I. J. Llewellyn-Smith*, J. B. Minson, P. M. Pilowsky, L. F. Arnolda, J. P. Chalmers

*Corresponding author for this work

    Research output: Contribution to journalArticle

    59 Citations (Scopus)


    The synaptic input from glutamate- or γaminobutyric acid (GABA)-immunoreactive nerve fibers to sympathetic preganglionic neurons projecting to the superior cervical ganglion was assessed using retrograde tracing with cholera toxin B subunit and post-embedding immunogold labelling. Half the boutons that synapsed on or directly contacted this group of neurons were immunoreactive for glutamate and half were immunoreactive for GABA. In previous studies, about 2/3 of the synapses on sympathoadrenal neurons were found to be glutamate-immunoreactive and about 1/3, GABA immunoreactive and these two amino acids were not co-localized. Thus, 100% of the boutons that synapse on sympathetic preganglionic neurons supplying the superior cervical ganglion or the adrenal medulla are likely to contain either glutamate or GABA. Anterograde tracing combined with amino acid immunocytochemistry indicated that at least some glutamate-containing and some GABA-containing nerve fibers in the intermediolateral cell column could come from the rostral ventral medulla.

    Original languageEnglish
    Pages (from-to)323-333
    Number of pages11
    JournalClinical and Experimental Hypertension
    Issue number1-2
    Publication statusPublished - 1995

    Fingerprint Dive into the research topics of 'The one hundred percent hypothesis: Glutamate or gaba in synapses on sympathetic preganglionic neurons'. Together they form a unique fingerprint.

    Cite this