The ototoxic mechanism of cisplatin

David McAlpine*, Brian M. Johnstone

*Corresponding author for this work

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

The ototoxic mechanism of cisplatin was investigated. Potentiation of cisplatin ototoxicity by furosemide and amino-oxyacetic acid (AOAA) was observed. Substantial hearing loss in cisplatin-deafened animals was accompanied by normal values of the endocochlear potential and a reduction in the sensitivity of the 2f1-f2 distortion products. The loss in dB of the sensitivity of the distortion products correlated extremely well with the loss of the neural sensitivity in dB. There was also a relationship between the fractional reduction of the low frequency (1000 Hz) microphonic potential and hearing loss in dB. Iontophoresis of cisplatin into scala media resulting in the immediate loss of neural thresholds at the site of iontophoresis. It is concluded that cisplatin caused the hearing loss by blocking OHC transduction channels.

Original languageEnglish
Pages (from-to)191-203
Number of pages13
JournalHearing Research
Volume47
Issue number3
DOIs
Publication statusPublished - 15 Aug 1990
Externally publishedYes

Keywords

  • Cisplatin
  • Cochlear microphonic
  • Distortion products
  • Potentiation

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