The pathological damage in duchenne muscular dystrophy may be due to increased intracellular oxy-radical generation caused by the absence of dystrophin and subsequent alterations in Ca2+ metabolism

M. S. Baker, L. Austin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

Recent advances in the genetic and molecular pathogenesis of Duchenne muscular dystrophy and the evidence suggesting a role for oxygen free radicals (oxy-radicals) in the development of this disease are reviewed. In addition, we outline a working of hypothesis as to how disruptions in intracellular Ca2+ homeostasis within the dystrophic cell may initiate cycles of increased oxy-radical fluxes within these cells, leading to intracellular oxidative damage.

Original languageEnglish
Pages (from-to)187-193
Number of pages7
JournalMedical Hypotheses
Volume29
Issue number3
DOIs
Publication statusPublished - 1989
Externally publishedYes

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