The phylogenomics of evolving virus virulence

Jemma L. Geoghegan, Edward C. Holmes*

*Corresponding author for this work

Research output: Contribution to journalReview article

26 Citations (Scopus)

Abstract

How virulence evolves after a virus jumps to a new host species is central to disease emergence. Our current understanding of virulence evolution is based on insights drawn from two perspectives that have developed largely independently: long-standing evolutionary theory based on limited real data examples that often lack a genomic basis, and experimental studies of virulence-determining mutations using cell culture or animal models. A more comprehensive understanding of virulence mutations and their evolution can be achieved by bridging the gap between these two research pathways through the phylogenomic analysis of virus genome sequence data as a guide to experimental study.

Original languageEnglish
Pages (from-to)756–769
Number of pages14
JournalNature Reviews Genetics
Volume19
Issue number12
Early online date10 Oct 2018
DOIs
Publication statusPublished - Dec 2018

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