The Potential Applications of ZnO Nanoparticles Conjugated with ALA and Photofrin as a Biomarker in HepG2 Cells

M. Fakhar-e-Alam*, S. Firdous, M. Atif, Y. Khan, S. S Z Zaidi, R. Suleman, A. Rehman, R. U. Khan, M. Nawaz, M. Ikram

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

Drug delivery into the malignant cell is a basic requirement for effectiveness of photosensitizing systems for photodynamic therapy (PDT). For anticancer tumoricidal drugs, e.g., 5-aminolevulinic acid (ALA), zinc oxide (ZnO) nanoparticles (NPs) are used as efficient intracellular photosensitizer carriers. Apoptotic effect of tumoricidal drugs (ALA and Photofrin®) is studied in HepG2 (Hepatucellular carcinoma) cells in the presence and absence of ZnO NPs using confocal microscopy as well as Neutral Red Assay (NRA). In dark, ZnO NPs conjugated with ALA or Photofrin® has been found to have a remarkable fluorescence in Hepatucellular carcinoma (HepG2) cells. This fact illustrates the great potential of ZnO NPs as biomarker in relevant clinical and biomedical applications.

Original languageEnglish
Pages (from-to)2156-2164
Number of pages9
JournalLaser Physics
Volume21
Issue number12
DOIs
Publication statusPublished - Dec 2011
Externally publishedYes

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