The Potential Applications of ZnO Nanoparticles Conjugated with ALA and Photofrin as a Biomarker in HepG2 Cells

M. Fakhar-e-Alam; S. Firdous; M. Atif; Y. Khan; S. S Z Zaidi; R. Suleman; A. Rehman; R. U. Khan; M. Nawaz; M. Ikram

doi:10.1134/S1054660X11210067

The Potential Applications of ZnO Nanoparticles Conjugated with ALA and Photofrin as a Biomarker in HepG2 Cells

M. Fakhar-e-Alam^*, S. Firdous, M. Atif, Y. Khan, S. S Z Zaidi, R. Suleman, A. Rehman, R. U. Khan, M. Nawaz, M. Ikram

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Drug delivery into the malignant cell is a basic requirement for effectiveness of photosensitizing systems for photodynamic therapy (PDT). For anticancer tumoricidal drugs, e.g., 5-aminolevulinic acid (ALA), zinc oxide (ZnO) nanoparticles (NPs) are used as efficient intracellular photosensitizer carriers. Apoptotic effect of tumoricidal drugs (ALA and Photofrin®) is studied in HepG2 (Hepatucellular carcinoma) cells in the presence and absence of ZnO NPs using confocal microscopy as well as Neutral Red Assay (NRA). In dark, ZnO NPs conjugated with ALA or Photofrin® has been found to have a remarkable fluorescence in Hepatucellular carcinoma (HepG2) cells. This fact illustrates the great potential of ZnO NPs as biomarker in relevant clinical and biomedical applications.

Original language	English
Pages (from-to)	2156-2164
Number of pages	9
Journal	Laser Physics
Volume	21
Issue number	12
DOIs	https://doi.org/10.1134/S1054660X11210067
Publication status	Published - Dec 2011
Externally published	Yes

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title = "The Potential Applications of ZnO Nanoparticles Conjugated with ALA and Photofrin as a Biomarker in HepG2 Cells",

abstract = "Drug delivery into the malignant cell is a basic requirement for effectiveness of photosensitizing systems for photodynamic therapy (PDT). For anticancer tumoricidal drugs, e.g., 5-aminolevulinic acid (ALA), zinc oxide (ZnO) nanoparticles (NPs) are used as efficient intracellular photosensitizer carriers. Apoptotic effect of tumoricidal drugs (ALA and Photofrin{\textregistered}) is studied in HepG2 (Hepatucellular carcinoma) cells in the presence and absence of ZnO NPs using confocal microscopy as well as Neutral Red Assay (NRA). In dark, ZnO NPs conjugated with ALA or Photofrin{\textregistered} has been found to have a remarkable fluorescence in Hepatucellular carcinoma (HepG2) cells. This fact illustrates the great potential of ZnO NPs as biomarker in relevant clinical and biomedical applications.",

author = "M. Fakhar-e-Alam and S. Firdous and M. Atif and Y. Khan and Zaidi, \{S. S Z\} and R. Suleman and A. Rehman and Khan, \{R. U.\} and M. Nawaz and M. Ikram",

year = "2011",

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doi = "10.1134/S1054660X11210067",

language = "English",

volume = "21",

pages = "2156--2164",

journal = "Laser Physics",

issn = "1054-660X",

publisher = "Institute of Physics Publishing",

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TY - JOUR

T1 - The Potential Applications of ZnO Nanoparticles Conjugated with ALA and Photofrin as a Biomarker in HepG2 Cells

AU - Fakhar-e-Alam, M.

AU - Firdous, S.

AU - Atif, M.

AU - Khan, Y.

AU - Zaidi, S. S Z

AU - Suleman, R.

AU - Rehman, A.

AU - Khan, R. U.

AU - Nawaz, M.

AU - Ikram, M.

PY - 2011/12

Y1 - 2011/12

N2 - Drug delivery into the malignant cell is a basic requirement for effectiveness of photosensitizing systems for photodynamic therapy (PDT). For anticancer tumoricidal drugs, e.g., 5-aminolevulinic acid (ALA), zinc oxide (ZnO) nanoparticles (NPs) are used as efficient intracellular photosensitizer carriers. Apoptotic effect of tumoricidal drugs (ALA and Photofrin®) is studied in HepG2 (Hepatucellular carcinoma) cells in the presence and absence of ZnO NPs using confocal microscopy as well as Neutral Red Assay (NRA). In dark, ZnO NPs conjugated with ALA or Photofrin® has been found to have a remarkable fluorescence in Hepatucellular carcinoma (HepG2) cells. This fact illustrates the great potential of ZnO NPs as biomarker in relevant clinical and biomedical applications.

AB - Drug delivery into the malignant cell is a basic requirement for effectiveness of photosensitizing systems for photodynamic therapy (PDT). For anticancer tumoricidal drugs, e.g., 5-aminolevulinic acid (ALA), zinc oxide (ZnO) nanoparticles (NPs) are used as efficient intracellular photosensitizer carriers. Apoptotic effect of tumoricidal drugs (ALA and Photofrin®) is studied in HepG2 (Hepatucellular carcinoma) cells in the presence and absence of ZnO NPs using confocal microscopy as well as Neutral Red Assay (NRA). In dark, ZnO NPs conjugated with ALA or Photofrin® has been found to have a remarkable fluorescence in Hepatucellular carcinoma (HepG2) cells. This fact illustrates the great potential of ZnO NPs as biomarker in relevant clinical and biomedical applications.

UR - https://www.scopus.com/pages/publications/84855894001

U2 - 10.1134/S1054660X11210067

DO - 10.1134/S1054660X11210067

M3 - Article

AN - SCOPUS:84855894001

SN - 1054-660X

VL - 21

SP - 2156

EP - 2164

JO - Laser Physics

JF - Laser Physics

IS - 12

ER -

The Potential Applications of ZnO Nanoparticles Conjugated with ALA and Photofrin as a Biomarker in HepG2 Cells

Abstract

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