The potential use of Raman mapping to investigate in vitro deposition of combination pressurized metered-dose inhalers

D. Fraser Steele, Paul M. Young, Robert Price, Timothy Smith, Stephen Edge, David Lewis

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Scanning near-infrared Raman microscopy has been used to map aerosol particulate deposits produced from pressurized metered-dose inhalers (pMDI). A commercially available combination asthma therapy pMDI (Ventide, Allen and Hanbury, UK), containing salbutamol and beclometasone dipropionate, was analyzed by conventional in vitro quantitative analysis and scanning Raman microscopy. Raman maps, taken from Andersen cascade impactor plate stages 3 and 5 (over 100 × 100 μm areas) suggested good correlation with chemical analysis of the respective stages. Scanning Raman microscopy allows visual differentiation between formulation components (not possible using conventional imaging techniques), while potentially allowing chemical quantification.
Original languageEnglish
Pages (from-to)41-44
Number of pages4
JournalAAPS Journal
Volume6
Issue number4
DOIs
Publication statusPublished - Dec 2004
Externally publishedYes

Keywords

  • pMDIs
  • combination therapy
  • Raman mapping
  • SEM
  • Andersen Cascade Impactor

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