The potential use of Raman mapping to investigate in vitro deposition of combination pressurized metered-dose inhalers

D. Fraser Steele; Paul M. Young; Robert Price; Timothy Smith; Stephen Edge; David Lewis

doi:10.1208/aapsj060432

The potential use of Raman mapping to investigate in vitro deposition of combination pressurized metered-dose inhalers

D. Fraser Steele, Paul M. Young, Robert Price, Timothy Smith, Stephen Edge, David Lewis

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Scanning near-infrared Raman microscopy has been used to map aerosol particulate deposits produced from pressurized metered-dose inhalers (pMDI). A commercially available combination asthma therapy pMDI (Ventide, Allen and Hanbury, UK), containing salbutamol and beclometasone dipropionate, was analyzed by conventional in vitro quantitative analysis and scanning Raman microscopy. Raman maps, taken from Andersen cascade impactor plate stages 3 and 5 (over 100 × 100 μm areas) suggested good correlation with chemical analysis of the respective stages. Scanning Raman microscopy allows visual differentiation between formulation components (not possible using conventional imaging techniques), while potentially allowing chemical quantification.

Original language	English
Pages (from-to)	41-44
Number of pages	4
Journal	AAPS Journal
Volume	6
Issue number	4
DOIs	https://doi.org/10.1208/aapsj060432
Publication status	Published - Dec 2004
Externally published	Yes

Keywords

pMDIs
combination therapy
Raman mapping
SEM
Andersen Cascade Impactor

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10.1208/aapsj060432

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title = "The potential use of Raman mapping to investigate in vitro deposition of combination pressurized metered-dose inhalers",

abstract = "Scanning near-infrared Raman microscopy has been used to map aerosol particulate deposits produced from pressurized metered-dose inhalers (pMDI). A commercially available combination asthma therapy pMDI (Ventide, Allen and Hanbury, UK), containing salbutamol and beclometasone dipropionate, was analyzed by conventional in vitro quantitative analysis and scanning Raman microscopy. Raman maps, taken from Andersen cascade impactor plate stages 3 and 5 (over 100 × 100 μm areas) suggested good correlation with chemical analysis of the respective stages. Scanning Raman microscopy allows visual differentiation between formulation components (not possible using conventional imaging techniques), while potentially allowing chemical quantification.",

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AU - Price, Robert

AU - Smith, Timothy

AU - Edge, Stephen

AU - Lewis, David

PY - 2004/12

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AB - Scanning near-infrared Raman microscopy has been used to map aerosol particulate deposits produced from pressurized metered-dose inhalers (pMDI). A commercially available combination asthma therapy pMDI (Ventide, Allen and Hanbury, UK), containing salbutamol and beclometasone dipropionate, was analyzed by conventional in vitro quantitative analysis and scanning Raman microscopy. Raman maps, taken from Andersen cascade impactor plate stages 3 and 5 (over 100 × 100 μm areas) suggested good correlation with chemical analysis of the respective stages. Scanning Raman microscopy allows visual differentiation between formulation components (not possible using conventional imaging techniques), while potentially allowing chemical quantification.

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The potential use of Raman mapping to investigate in vitro deposition of combination pressurized metered-dose inhalers

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Keywords

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