The presence of arachnoiditis affects the characteristics of CSF flow in the spinal subarachnoid space: A modelling study

Shaokoon Cheng, Marcus A. Stoodley, Johnny Wong, Sarah Hemley, David F. Fletcher, Lynne E. Bilston

    Research output: Contribution to journalArticleResearchpeer-review

    Abstract

    Syringomyelia is a neurological disorder characterised by high pressure fluid-filled cysts within the spinal cord. As syringomyelia is associated with abnormalities of the central nervous system that obstruct cerebrospinal fluid (CSF) flow, it is thought that changes in CSF dynamics play an important role in its pathogenesis. Using three-dimensional computational models of the spinal subarachnoid space (SAS), this study aims to determine SAS obstructions, such as arachnoiditis, change in CSF dynamics in the SAS. The geometry of the SAS was reconstructed from a series of MRI images. CSF is modelled as an incompressible Newtonian fluid with a dynamic viscosity of 1. mPa. s. Three computational models simulated CSF flow in either the unobstructed SAS, or with the SAS obstructed by a porous region simulating dorsal or circumferential arachnoiditis. The permeability of this porous obstruction was varied for the model with dorsal arachnoiditis. The results show that arachnoiditis increases flow resistance in the SAS and this is accompanied by a modest increase in magnitude and/or shift in timing (with respect to the cardiac cycle) of the CSF pressure drop across the region of arachnoiditis. This study suggests that syrinx formation may be related to a change in temporal CSF pulse pressure dynamics.

    LanguageEnglish
    Pages1186-1191
    Number of pages6
    JournalJournal of Biomechanics
    Volume45
    Issue number7
    DOIs
    Publication statusPublished - 30 Apr 2012

    Fingerprint

    Arachnoiditis
    Cerebrospinal fluid
    Subarachnoid Space
    Cerebrospinal Fluid
    Flow of fluids
    Cerebrospinal Fluid Pressure
    Syringomyelia
    Hydrodynamics
    Fluid dynamics
    Cyst Fluid
    Syringes
    Fluids
    Neurology
    Nervous System Diseases
    Viscosity
    Magnetic resonance imaging
    Pressure drop
    Permeability
    Spinal Cord
    Central Nervous System

    Cite this

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    title = "The presence of arachnoiditis affects the characteristics of CSF flow in the spinal subarachnoid space: A modelling study",
    abstract = "Syringomyelia is a neurological disorder characterised by high pressure fluid-filled cysts within the spinal cord. As syringomyelia is associated with abnormalities of the central nervous system that obstruct cerebrospinal fluid (CSF) flow, it is thought that changes in CSF dynamics play an important role in its pathogenesis. Using three-dimensional computational models of the spinal subarachnoid space (SAS), this study aims to determine SAS obstructions, such as arachnoiditis, change in CSF dynamics in the SAS. The geometry of the SAS was reconstructed from a series of MRI images. CSF is modelled as an incompressible Newtonian fluid with a dynamic viscosity of 1. mPa. s. Three computational models simulated CSF flow in either the unobstructed SAS, or with the SAS obstructed by a porous region simulating dorsal or circumferential arachnoiditis. The permeability of this porous obstruction was varied for the model with dorsal arachnoiditis. The results show that arachnoiditis increases flow resistance in the SAS and this is accompanied by a modest increase in magnitude and/or shift in timing (with respect to the cardiac cycle) of the CSF pressure drop across the region of arachnoiditis. This study suggests that syrinx formation may be related to a change in temporal CSF pulse pressure dynamics.",
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    The presence of arachnoiditis affects the characteristics of CSF flow in the spinal subarachnoid space : A modelling study. / Cheng, Shaokoon; Stoodley, Marcus A.; Wong, Johnny; Hemley, Sarah; Fletcher, David F.; Bilston, Lynne E.

    In: Journal of Biomechanics, Vol. 45, No. 7, 30.04.2012, p. 1186-1191.

    Research output: Contribution to journalArticleResearchpeer-review

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    T2 - Journal of Biomechanics

    AU - Cheng, Shaokoon

    AU - Stoodley, Marcus A.

    AU - Wong, Johnny

    AU - Hemley, Sarah

    AU - Fletcher, David F.

    AU - Bilston, Lynne E.

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    Y1 - 2012/4/30

    N2 - Syringomyelia is a neurological disorder characterised by high pressure fluid-filled cysts within the spinal cord. As syringomyelia is associated with abnormalities of the central nervous system that obstruct cerebrospinal fluid (CSF) flow, it is thought that changes in CSF dynamics play an important role in its pathogenesis. Using three-dimensional computational models of the spinal subarachnoid space (SAS), this study aims to determine SAS obstructions, such as arachnoiditis, change in CSF dynamics in the SAS. The geometry of the SAS was reconstructed from a series of MRI images. CSF is modelled as an incompressible Newtonian fluid with a dynamic viscosity of 1. mPa. s. Three computational models simulated CSF flow in either the unobstructed SAS, or with the SAS obstructed by a porous region simulating dorsal or circumferential arachnoiditis. The permeability of this porous obstruction was varied for the model with dorsal arachnoiditis. The results show that arachnoiditis increases flow resistance in the SAS and this is accompanied by a modest increase in magnitude and/or shift in timing (with respect to the cardiac cycle) of the CSF pressure drop across the region of arachnoiditis. This study suggests that syrinx formation may be related to a change in temporal CSF pulse pressure dynamics.

    AB - Syringomyelia is a neurological disorder characterised by high pressure fluid-filled cysts within the spinal cord. As syringomyelia is associated with abnormalities of the central nervous system that obstruct cerebrospinal fluid (CSF) flow, it is thought that changes in CSF dynamics play an important role in its pathogenesis. Using three-dimensional computational models of the spinal subarachnoid space (SAS), this study aims to determine SAS obstructions, such as arachnoiditis, change in CSF dynamics in the SAS. The geometry of the SAS was reconstructed from a series of MRI images. CSF is modelled as an incompressible Newtonian fluid with a dynamic viscosity of 1. mPa. s. Three computational models simulated CSF flow in either the unobstructed SAS, or with the SAS obstructed by a porous region simulating dorsal or circumferential arachnoiditis. The permeability of this porous obstruction was varied for the model with dorsal arachnoiditis. The results show that arachnoiditis increases flow resistance in the SAS and this is accompanied by a modest increase in magnitude and/or shift in timing (with respect to the cardiac cycle) of the CSF pressure drop across the region of arachnoiditis. This study suggests that syrinx formation may be related to a change in temporal CSF pulse pressure dynamics.

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