The prevalence and clinical correlates of apathy and irritability in Alzheimer's disease

S. E. Starkstein; R. Migliorelli; F. Manes; A. Tesón; G. Petracca; E. Chemerinski; L. Sabe; R. Leiguarda

doi:10.1111/j.1468-1331.1995.tb00171.x

The prevalence and clinical correlates of apathy and irritability in Alzheimer's disease

S. E. Starkstein^*, R. Migliorelli, F. Manes, A. Tesón, G. Petracca, E. Chemerinski, L. Sabe, R. Leiguarda

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

66 Citations (Scopus)

Abstract

We examined the prevalence and correlates of apathy and irritability in a consecutive series of 101 patients with probable Alzheimer's disease (AD). Based on clinical criteria, 46 (46%) patients had apathy, and 13 (13%) patients had irritability. Apathy was significantly associated with more severe impairments in activities of daily living, significantly more severe extrapyramidal signs, and a significantly higher frequency of both major depression and dysthymia. Patients with irritability had significantly more severe impairments in activities of daily living and significantly higher depression and anosognosia scores. On the other hand, neither apathy nor irritability were significantly associated with deficits in specific cognitive domains. 1995 Lippincott Williams & Wilkins

Original language	English
Pages (from-to)	540-546
Number of pages	7
Journal	European Journal of Neurology
Volume	2
Issue number	6
DOIs	https://doi.org/10.1111/j.1468-1331.1995.tb00171.x
Publication status	Published - 1995
Externally published	Yes

Keywords

Alzheimer's disease
Apathy
Irritability

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10.1111/j.1468-1331.1995.tb00171.x

Cite this

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title = "The prevalence and clinical correlates of apathy and irritability in Alzheimer's disease",

abstract = "We examined the prevalence and correlates of apathy and irritability in a consecutive series of 101 patients with probable Alzheimer's disease (AD). Based on clinical criteria, 46 (46%) patients had apathy, and 13 (13%) patients had irritability. Apathy was significantly associated with more severe impairments in activities of daily living, significantly more severe extrapyramidal signs, and a significantly higher frequency of both major depression and dysthymia. Patients with irritability had significantly more severe impairments in activities of daily living and significantly higher depression and anosognosia scores. On the other hand, neither apathy nor irritability were significantly associated with deficits in specific cognitive domains. 1995 Lippincott Williams & Wilkins",

keywords = "Alzheimer's disease, Apathy, Irritability",

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T1 - The prevalence and clinical correlates of apathy and irritability in Alzheimer's disease

AU - Starkstein, S. E.

AU - Migliorelli, R.

AU - Manes, F.

AU - Tesón, A.

AU - Petracca, G.

AU - Chemerinski, E.

AU - Sabe, L.

AU - Leiguarda, R.

PY - 1995

Y1 - 1995

N2 - We examined the prevalence and correlates of apathy and irritability in a consecutive series of 101 patients with probable Alzheimer's disease (AD). Based on clinical criteria, 46 (46%) patients had apathy, and 13 (13%) patients had irritability. Apathy was significantly associated with more severe impairments in activities of daily living, significantly more severe extrapyramidal signs, and a significantly higher frequency of both major depression and dysthymia. Patients with irritability had significantly more severe impairments in activities of daily living and significantly higher depression and anosognosia scores. On the other hand, neither apathy nor irritability were significantly associated with deficits in specific cognitive domains. 1995 Lippincott Williams & Wilkins

AB - We examined the prevalence and correlates of apathy and irritability in a consecutive series of 101 patients with probable Alzheimer's disease (AD). Based on clinical criteria, 46 (46%) patients had apathy, and 13 (13%) patients had irritability. Apathy was significantly associated with more severe impairments in activities of daily living, significantly more severe extrapyramidal signs, and a significantly higher frequency of both major depression and dysthymia. Patients with irritability had significantly more severe impairments in activities of daily living and significantly higher depression and anosognosia scores. On the other hand, neither apathy nor irritability were significantly associated with deficits in specific cognitive domains. 1995 Lippincott Williams & Wilkins

KW - Alzheimer's disease

KW - Apathy

KW - Irritability

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DO - 10.1111/j.1468-1331.1995.tb00171.x

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The prevalence and clinical correlates of apathy and irritability in Alzheimer's disease

Abstract

Keywords

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