The prevalence of mild cognitive impairment in diverse geographical and ethnocultural regions: the COSMIC Collaboration

Perminder S. Sachdev; Darren M. Lipnicki; Nicole A. Kochan; John D. Crawford; Anbupalam Thalamuthu; Gavin Andrews; Carol Brayne; Fiona E. Matthews; Blossom C M Stephan; Richard B. Lipton; Mindy J. Katz; Karen Ritchie; Isabelle Carrière; Marie-Laure Ancelin; Linda C W Lam; Candy H Y Wong; Ada W T Fung; Antonio Guaita; Roberta Vaccaro; Annalisa Davin; Mary Ganguli; Hiroko Dodge; Tiffany Hughes; Kaarin J. Anstey; Nicolas Cherbuin; Peter Butterworth; Tze Pin Ng; Qi Gao; Simone Reppermund; Henry Brodaty; Nicole Schupf; Jennifer Manly; Yaakov Stern; Antonio Lobo; Raùl Lopez-Anton; Javier Santabárbara; Cohort Studies of Memory in an International Consortium (COSMIC)

doi:10.1371/journal.pone.0142388

The prevalence of mild cognitive impairment in diverse geographical and ethnocultural regions: the COSMIC Collaboration

Perminder S. Sachdev, Darren M. Lipnicki, Nicole A. Kochan, John D. Crawford, Anbupalam Thalamuthu, Gavin Andrews, Carol Brayne, Fiona E. Matthews, Blossom C M Stephan, Richard B. Lipton, Mindy J. Katz, Karen Ritchie, Isabelle Carrière, Marie-Laure Ancelin, Linda C W Lam, Candy H Y Wong, Ada W T Fung, Antonio Guaita, Roberta Vaccaro, Annalisa DavinMary Ganguli, Hiroko Dodge, Tiffany Hughes, Kaarin J. Anstey, Nicolas Cherbuin, Peter Butterworth, Tze Pin Ng, Qi Gao, Simone Reppermund, Henry Brodaty, Nicole Schupf, Jennifer Manly, Yaakov Stern, Antonio Lobo, Raùl Lopez-Anton, Javier Santabárbara, Cohort Studies of Memory in an International Consortium (COSMIC)

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Abstract

BACKGROUND: Changes in criteria and differences in populations studied and methodology have produced a wide range of prevalence estimates for mild cognitive impairment (MCI).

METHODS: Uniform criteria were applied to harmonized data from 11 studies from USA, Europe, Asia and Australia, and MCI prevalence estimates determined using three separate definitions of cognitive impairment.

RESULTS: The published range of MCI prevalence estimates was 5.0%-36.7%. This was reduced with all cognitive impairment definitions: performance in the bottom 6.681% (3.2%-10.8%); Clinical Dementia Rating of 0.5 (1.8%-14.9%); Mini-Mental State Examination score of 24-27 (2.1%-20.7%). Prevalences using the first definition were 5.9% overall, and increased with age (P < .001) but were unaffected by sex or the main races/ethnicities investigated (Whites and Chinese). Not completing high school increased the likelihood of MCI (P ≤ .01).

CONCLUSION: Applying uniform criteria to harmonized data greatly reduced the variation in MCI prevalence internationally.

Original language	English
Article number	e0142388
Pages (from-to)	1-19
Number of pages	19
Journal	PLoS ONE
Volume	10
Issue number	11
DOIs	https://doi.org/10.1371/journal.pone.0142388
Publication status	Published - 5 Nov 2015
Externally published	Yes

Bibliographical note

Copyright the Author(s) 2015. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

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Sachdev, P. S., Lipnicki, D. M., Kochan, N. A., Crawford, J. D., Thalamuthu, A., Andrews, G., Brayne, C., Matthews, F. E., Stephan, B. C. M., Lipton, R. B., Katz, M. J., Ritchie, K., Carrière, I., Ancelin, M-L., Lam, L. C. W., Wong, C. H. Y., Fung, A. W. T., Guaita, A., Vaccaro, R., ... Cohort Studies of Memory in an International Consortium (COSMIC) (2015). The prevalence of mild cognitive impairment in diverse geographical and ethnocultural regions: the COSMIC Collaboration. PLoS ONE, 10(11), 1-19. [e0142388]. https://doi.org/10.1371/journal.pone.0142388

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title = "The prevalence of mild cognitive impairment in diverse geographical and ethnocultural regions: the COSMIC Collaboration",

abstract = "BACKGROUND: Changes in criteria and differences in populations studied and methodology have produced a wide range of prevalence estimates for mild cognitive impairment (MCI).METHODS: Uniform criteria were applied to harmonized data from 11 studies from USA, Europe, Asia and Australia, and MCI prevalence estimates determined using three separate definitions of cognitive impairment.RESULTS: The published range of MCI prevalence estimates was 5.0%-36.7%. This was reduced with all cognitive impairment definitions: performance in the bottom 6.681% (3.2%-10.8%); Clinical Dementia Rating of 0.5 (1.8%-14.9%); Mini-Mental State Examination score of 24-27 (2.1%-20.7%). Prevalences using the first definition were 5.9% overall, and increased with age (P < .001) but were unaffected by sex or the main races/ethnicities investigated (Whites and Chinese). Not completing high school increased the likelihood of MCI (P ≤ .01).CONCLUSION: Applying uniform criteria to harmonized data greatly reduced the variation in MCI prevalence internationally.",

author = "Sachdev, {Perminder S.} and Lipnicki, {Darren M.} and Kochan, {Nicole A.} and Crawford, {John D.} and Anbupalam Thalamuthu and Gavin Andrews and Carol Brayne and Matthews, {Fiona E.} and Stephan, {Blossom C M} and Lipton, {Richard B.} and Katz, {Mindy J.} and Karen Ritchie and Isabelle Carri{\`e}re and Marie-Laure Ancelin and Lam, {Linda C W} and Wong, {Candy H Y} and Fung, {Ada W T} and Antonio Guaita and Roberta Vaccaro and Annalisa Davin and Mary Ganguli and Hiroko Dodge and Tiffany Hughes and Anstey, {Kaarin J.} and Nicolas Cherbuin and Peter Butterworth and Ng, {Tze Pin} and Qi Gao and Simone Reppermund and Henry Brodaty and Nicole Schupf and Jennifer Manly and Yaakov Stern and Antonio Lobo and Ra{\`u}l Lopez-Anton and Javier Santab{\'a}rbara and Sarah Jacek and Donna McCade and {Cohort Studies of Memory in an International Consortium (COSMIC)}",

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Sachdev, PS, Lipnicki, DM, Kochan, NA, Crawford, JD, Thalamuthu, A, Andrews, G, Brayne, C, Matthews, FE, Stephan, BCM, Lipton, RB, Katz, MJ, Ritchie, K, Carrière, I, Ancelin, M-L, Lam, LCW, Wong, CHY, Fung, AWT, Guaita, A, Vaccaro, R, Davin, A, Ganguli, M, Dodge, H, Hughes, T, Anstey, KJ, Cherbuin, N, Butterworth, P, Ng, TP, Gao, Q, Reppermund, S, Brodaty, H, Schupf, N, Manly, J, Stern, Y, Lobo, A, Lopez-Anton, R, Santabárbara, J & Cohort Studies of Memory in an International Consortium (COSMIC) 2015, 'The prevalence of mild cognitive impairment in diverse geographical and ethnocultural regions: the COSMIC Collaboration', PLoS ONE, vol. 10, no. 11, e0142388, pp. 1-19. https://doi.org/10.1371/journal.pone.0142388

TY - JOUR

T1 - The prevalence of mild cognitive impairment in diverse geographical and ethnocultural regions

T2 - the COSMIC Collaboration

AU - Sachdev, Perminder S.

AU - Lipnicki, Darren M.

AU - Kochan, Nicole A.

AU - Crawford, John D.

AU - Thalamuthu, Anbupalam

AU - Andrews, Gavin

AU - Brayne, Carol

AU - Matthews, Fiona E.

AU - Stephan, Blossom C M

AU - Lipton, Richard B.

AU - Katz, Mindy J.

AU - Ritchie, Karen

AU - Carrière, Isabelle

AU - Ancelin, Marie-Laure

AU - Lam, Linda C W

AU - Wong, Candy H Y

AU - Fung, Ada W T

AU - Guaita, Antonio

AU - Vaccaro, Roberta

AU - Davin, Annalisa

AU - Ganguli, Mary

AU - Dodge, Hiroko

AU - Hughes, Tiffany

AU - Anstey, Kaarin J.

AU - Cherbuin, Nicolas

AU - Butterworth, Peter

AU - Ng, Tze Pin

AU - Gao, Qi

AU - Reppermund, Simone

AU - Brodaty, Henry

AU - Schupf, Nicole

AU - Manly, Jennifer

AU - Stern, Yaakov

AU - Lobo, Antonio

AU - Lopez-Anton, Raùl

AU - Santabárbara, Javier

AU - Jacek, Sarah

AU - McCade, Donna

AU - Cohort Studies of Memory in an International Consortium (COSMIC)

N1 - Copyright the Author(s) 2015. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2015/11/5

Y1 - 2015/11/5

N2 - BACKGROUND: Changes in criteria and differences in populations studied and methodology have produced a wide range of prevalence estimates for mild cognitive impairment (MCI).METHODS: Uniform criteria were applied to harmonized data from 11 studies from USA, Europe, Asia and Australia, and MCI prevalence estimates determined using three separate definitions of cognitive impairment.RESULTS: The published range of MCI prevalence estimates was 5.0%-36.7%. This was reduced with all cognitive impairment definitions: performance in the bottom 6.681% (3.2%-10.8%); Clinical Dementia Rating of 0.5 (1.8%-14.9%); Mini-Mental State Examination score of 24-27 (2.1%-20.7%). Prevalences using the first definition were 5.9% overall, and increased with age (P < .001) but were unaffected by sex or the main races/ethnicities investigated (Whites and Chinese). Not completing high school increased the likelihood of MCI (P ≤ .01).CONCLUSION: Applying uniform criteria to harmonized data greatly reduced the variation in MCI prevalence internationally.

AB - BACKGROUND: Changes in criteria and differences in populations studied and methodology have produced a wide range of prevalence estimates for mild cognitive impairment (MCI).METHODS: Uniform criteria were applied to harmonized data from 11 studies from USA, Europe, Asia and Australia, and MCI prevalence estimates determined using three separate definitions of cognitive impairment.RESULTS: The published range of MCI prevalence estimates was 5.0%-36.7%. This was reduced with all cognitive impairment definitions: performance in the bottom 6.681% (3.2%-10.8%); Clinical Dementia Rating of 0.5 (1.8%-14.9%); Mini-Mental State Examination score of 24-27 (2.1%-20.7%). Prevalences using the first definition were 5.9% overall, and increased with age (P < .001) but were unaffected by sex or the main races/ethnicities investigated (Whites and Chinese). Not completing high school increased the likelihood of MCI (P ≤ .01).CONCLUSION: Applying uniform criteria to harmonized data greatly reduced the variation in MCI prevalence internationally.

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The prevalence of mild cognitive impairment in diverse geographical and ethnocultural regions: the COSMIC Collaboration

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