The prevalence, severity, and correlates of psychological distress and impaired health-related quality of life following treatment for testicular cancer: a survivorship study

Allan Ben Smith, Phyllis Butow, Ian Olver, Tim Luckett, Peter Grimison, Guy C. Toner, Martin R. Stockler, Elizabeth Hovey, John Stubbs, Sandra Turner, George Hruby, Howard Gurney, Mahmood Alam, Keith Cox, Madeleine T. King

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Purpose: This study aimed to establish the prevalence, severity, and correlates of psychological distress and impaired generic health-related quality of life (HRQOL) in testicular cancer (TC) survivors. Methods: Men who had completed active anti-cancer treatment for TC between 6 months and 5 years previously showing no evidence of recurrence were recruited from 14 Australian cancer centers from September 2009 to February 2011. Participants completed a self-report questionnaire measuring demographic, disease, and treatment information, psychological distress (i.e., depression, anxiety, and stress; DASS21), generic health-related quality of life (HRQOL; SF-36v2), TC-specific HRQOL (EORTC QLQ-TC26), coping (MAC), social support (DUFSS), and unmet needs (CaSUN). Results: Of 486 eligible TC survivors, 244 (50.2 %) completed the questionnaire. Compared with normative data, TC survivors reported: small but statistically significant increases in mean levels of anxiety and depression; a greater prevalence of moderate to extremely severe anxiety (19 %) and depression (20 %); and significant deficits to mostly mental aspects of generic HRQOL. The most problematic TC-specific HRQOL issues (e.g., fear of recurrence) were also more mental than physical. In multiple regression analyses, the strongest correlates of psychological distress and impaired generic HRQOL were psychosocial (e.g., helpless/hopeless coping and lower social support) rather than disease or treatment factors. Conclusions: Generally, TC survivors appear to experience mild psychological distress and HRQOL impairments, while a vulnerable subgroup experience more severe morbidity. Implications for Cancer Survivors: There is a need to identify TC survivors at risk of poorer outcomes and for interventions to target the areas of greatest impairment (i.e., psychological distress and mental HRQOL).

LanguageEnglish
Pages223-233
Number of pages11
JournalJournal of Cancer Survivorship
Volume10
Issue number2
DOIs
Publication statusPublished - 1 Apr 2016
Externally publishedYes

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Testicular Neoplasms
Survival Rate
Quality of Life
Psychology
Survivors
Therapeutics
Anxiety
Depression
Social Support
Recurrence
Neoplasms
Self Report
Fear
Mental Health
Regression Analysis
Demography
Morbidity

Keywords

  • Health-related quality of life
  • Oncology
  • Psychological distress
  • Survivorship
  • Testicular cancer

Cite this

Smith, Allan Ben ; Butow, Phyllis ; Olver, Ian ; Luckett, Tim ; Grimison, Peter ; Toner, Guy C. ; Stockler, Martin R. ; Hovey, Elizabeth ; Stubbs, John ; Turner, Sandra ; Hruby, George ; Gurney, Howard ; Alam, Mahmood ; Cox, Keith ; King, Madeleine T. / The prevalence, severity, and correlates of psychological distress and impaired health-related quality of life following treatment for testicular cancer : a survivorship study. In: Journal of Cancer Survivorship. 2016 ; Vol. 10, No. 2. pp. 223-233.
@article{81f547e2e244461fb1508f1f984d4616,
title = "The prevalence, severity, and correlates of psychological distress and impaired health-related quality of life following treatment for testicular cancer: a survivorship study",
abstract = "Purpose: This study aimed to establish the prevalence, severity, and correlates of psychological distress and impaired generic health-related quality of life (HRQOL) in testicular cancer (TC) survivors. Methods: Men who had completed active anti-cancer treatment for TC between 6 months and 5 years previously showing no evidence of recurrence were recruited from 14 Australian cancer centers from September 2009 to February 2011. Participants completed a self-report questionnaire measuring demographic, disease, and treatment information, psychological distress (i.e., depression, anxiety, and stress; DASS21), generic health-related quality of life (HRQOL; SF-36v2), TC-specific HRQOL (EORTC QLQ-TC26), coping (MAC), social support (DUFSS), and unmet needs (CaSUN). Results: Of 486 eligible TC survivors, 244 (50.2 {\%}) completed the questionnaire. Compared with normative data, TC survivors reported: small but statistically significant increases in mean levels of anxiety and depression; a greater prevalence of moderate to extremely severe anxiety (19 {\%}) and depression (20 {\%}); and significant deficits to mostly mental aspects of generic HRQOL. The most problematic TC-specific HRQOL issues (e.g., fear of recurrence) were also more mental than physical. In multiple regression analyses, the strongest correlates of psychological distress and impaired generic HRQOL were psychosocial (e.g., helpless/hopeless coping and lower social support) rather than disease or treatment factors. Conclusions: Generally, TC survivors appear to experience mild psychological distress and HRQOL impairments, while a vulnerable subgroup experience more severe morbidity. Implications for Cancer Survivors: There is a need to identify TC survivors at risk of poorer outcomes and for interventions to target the areas of greatest impairment (i.e., psychological distress and mental HRQOL).",
keywords = "Health-related quality of life, Oncology, Psychological distress, Survivorship, Testicular cancer",
author = "Smith, {Allan Ben} and Phyllis Butow and Ian Olver and Tim Luckett and Peter Grimison and Toner, {Guy C.} and Stockler, {Martin R.} and Elizabeth Hovey and John Stubbs and Sandra Turner and George Hruby and Howard Gurney and Mahmood Alam and Keith Cox and King, {Madeleine T.}",
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Smith, AB, Butow, P, Olver, I, Luckett, T, Grimison, P, Toner, GC, Stockler, MR, Hovey, E, Stubbs, J, Turner, S, Hruby, G, Gurney, H, Alam, M, Cox, K & King, MT 2016, 'The prevalence, severity, and correlates of psychological distress and impaired health-related quality of life following treatment for testicular cancer: a survivorship study', Journal of Cancer Survivorship, vol. 10, no. 2, pp. 223-233. https://doi.org/10.1007/s11764-015-0468-5

The prevalence, severity, and correlates of psychological distress and impaired health-related quality of life following treatment for testicular cancer : a survivorship study. / Smith, Allan Ben; Butow, Phyllis; Olver, Ian; Luckett, Tim; Grimison, Peter; Toner, Guy C.; Stockler, Martin R.; Hovey, Elizabeth; Stubbs, John; Turner, Sandra; Hruby, George; Gurney, Howard; Alam, Mahmood; Cox, Keith; King, Madeleine T.

In: Journal of Cancer Survivorship, Vol. 10, No. 2, 01.04.2016, p. 223-233.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - The prevalence, severity, and correlates of psychological distress and impaired health-related quality of life following treatment for testicular cancer

T2 - Journal of Cancer Survivorship

AU - Smith, Allan Ben

AU - Butow, Phyllis

AU - Olver, Ian

AU - Luckett, Tim

AU - Grimison, Peter

AU - Toner, Guy C.

AU - Stockler, Martin R.

AU - Hovey, Elizabeth

AU - Stubbs, John

AU - Turner, Sandra

AU - Hruby, George

AU - Gurney, Howard

AU - Alam, Mahmood

AU - Cox, Keith

AU - King, Madeleine T.

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Purpose: This study aimed to establish the prevalence, severity, and correlates of psychological distress and impaired generic health-related quality of life (HRQOL) in testicular cancer (TC) survivors. Methods: Men who had completed active anti-cancer treatment for TC between 6 months and 5 years previously showing no evidence of recurrence were recruited from 14 Australian cancer centers from September 2009 to February 2011. Participants completed a self-report questionnaire measuring demographic, disease, and treatment information, psychological distress (i.e., depression, anxiety, and stress; DASS21), generic health-related quality of life (HRQOL; SF-36v2), TC-specific HRQOL (EORTC QLQ-TC26), coping (MAC), social support (DUFSS), and unmet needs (CaSUN). Results: Of 486 eligible TC survivors, 244 (50.2 %) completed the questionnaire. Compared with normative data, TC survivors reported: small but statistically significant increases in mean levels of anxiety and depression; a greater prevalence of moderate to extremely severe anxiety (19 %) and depression (20 %); and significant deficits to mostly mental aspects of generic HRQOL. The most problematic TC-specific HRQOL issues (e.g., fear of recurrence) were also more mental than physical. In multiple regression analyses, the strongest correlates of psychological distress and impaired generic HRQOL were psychosocial (e.g., helpless/hopeless coping and lower social support) rather than disease or treatment factors. Conclusions: Generally, TC survivors appear to experience mild psychological distress and HRQOL impairments, while a vulnerable subgroup experience more severe morbidity. Implications for Cancer Survivors: There is a need to identify TC survivors at risk of poorer outcomes and for interventions to target the areas of greatest impairment (i.e., psychological distress and mental HRQOL).

AB - Purpose: This study aimed to establish the prevalence, severity, and correlates of psychological distress and impaired generic health-related quality of life (HRQOL) in testicular cancer (TC) survivors. Methods: Men who had completed active anti-cancer treatment for TC between 6 months and 5 years previously showing no evidence of recurrence were recruited from 14 Australian cancer centers from September 2009 to February 2011. Participants completed a self-report questionnaire measuring demographic, disease, and treatment information, psychological distress (i.e., depression, anxiety, and stress; DASS21), generic health-related quality of life (HRQOL; SF-36v2), TC-specific HRQOL (EORTC QLQ-TC26), coping (MAC), social support (DUFSS), and unmet needs (CaSUN). Results: Of 486 eligible TC survivors, 244 (50.2 %) completed the questionnaire. Compared with normative data, TC survivors reported: small but statistically significant increases in mean levels of anxiety and depression; a greater prevalence of moderate to extremely severe anxiety (19 %) and depression (20 %); and significant deficits to mostly mental aspects of generic HRQOL. The most problematic TC-specific HRQOL issues (e.g., fear of recurrence) were also more mental than physical. In multiple regression analyses, the strongest correlates of psychological distress and impaired generic HRQOL were psychosocial (e.g., helpless/hopeless coping and lower social support) rather than disease or treatment factors. Conclusions: Generally, TC survivors appear to experience mild psychological distress and HRQOL impairments, while a vulnerable subgroup experience more severe morbidity. Implications for Cancer Survivors: There is a need to identify TC survivors at risk of poorer outcomes and for interventions to target the areas of greatest impairment (i.e., psychological distress and mental HRQOL).

KW - Health-related quality of life

KW - Oncology

KW - Psychological distress

KW - Survivorship

KW - Testicular cancer

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U2 - 10.1007/s11764-015-0468-5

DO - 10.1007/s11764-015-0468-5

M3 - Article

VL - 10

SP - 223

EP - 233

JO - Journal of Cancer Survivorship

JF - Journal of Cancer Survivorship

SN - 1932-2259

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ER -