The rate of uptake of locally applied oestradiol and oestrone by the vaginal epithelium of the ovariectomized mouse

Irina Pollard*, L. Martin

*Corresponding author for this work

Research output: Contribution to journalArticle

3 Citations (Scopus)


The rate at which oestrogens reached their sites of action was investigated by the local application of dimethylstilboestrol at short intervals after the local application of each oestrogen. Receptor occupation appeared to be complete within 2–4 min. of the application of oestradiol-17β and of oestrone and in some cases with oestradiol within 1 min. However, such was the degree of variability between experiments that more precise estimates were not possible. These findings are discussed in relation to the mode of action of the oestrogens.
Original languageEnglish
Pages (from-to)71-76
Number of pages6
JournalJournal of Endocrinology
Issue number1
Publication statusPublished - 1 May 1967
Externally publishedYes


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