Abstract
2-Phenyl-4-hydroxyquinolines may be obtained directly from ethyl benzoylacetate and arylamines using polyphosphoric acid. Under certain conditions a mixture of benzoylacetanilide and β-arylaminocinnamate (or anil) is obtained. It is also shown that while the β-arylaminocinnamates give the expected 4-hydroxyquinolines on cyclization when heated with polyphosphoric acid, the benzoylacetanilides tend to give mixtures of the isomeric 2-hydroxy- and 4-hydroxyquinolines.
Original language | English |
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Pages (from-to) | 3191-3193 |
Number of pages | 3 |
Journal | Journal of Organic Chemistry |
Volume | 26 |
Issue number | 9 |
Publication status | Published - 1961 |