The relation of structural integrity and task-related functional connectivity in the aging brain

Hana Burianová*, Lars Marstaller, Jeiran Choupan, Farshid Sepehrband, Maryam Ziaei, David Reutens

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    10 Citations (Scopus)

    Abstract

    The relations among structural integrity, functional connectivity (FC), and cognitive performance in the aging brain are still understudied. Here, we used multimodal and multivariate approaches to specifically examine age-related changes in task-related FC, gray-matter volumetrics, white-matter integrity, and performance. Our results are two-fold, showing (i) age-related differences in FC of the working memory network and (ii) age-related recruitment of a compensatory network associated with better accuracy on the task. Increased connectivity in the compensatory network correlates positively with preserved white-matter integrity in bilateral frontoparietal tracks and with larger gray-matter volume of right inferior parietal lobule. These findings demonstrate the importance of structural integrity and FC in working memory performance associated with healthy aging.

    Original languageEnglish
    Pages (from-to)2830-2837
    Number of pages8
    JournalNeurobiology of Aging
    Volume36
    Issue number10
    DOIs
    Publication statusPublished - 1 Oct 2015

    Keywords

    • Age-related compensation
    • Functional connectivity
    • Gray matter
    • Structural integrity
    • White matter

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