TY - JOUR
T1 - The relation of structural integrity and task-related functional connectivity in the aging brain
AU - Burianová, Hana
AU - Marstaller, Lars
AU - Choupan, Jeiran
AU - Sepehrband, Farshid
AU - Ziaei, Maryam
AU - Reutens, David
PY - 2015/10/1
Y1 - 2015/10/1
N2 - The relations among structural integrity, functional connectivity (FC), and cognitive performance in the aging brain are still understudied. Here, we used multimodal and multivariate approaches to specifically examine age-related changes in task-related FC, gray-matter volumetrics, white-matter integrity, and performance. Our results are two-fold, showing (i) age-related differences in FC of the working memory network and (ii) age-related recruitment of a compensatory network associated with better accuracy on the task. Increased connectivity in the compensatory network correlates positively with preserved white-matter integrity in bilateral frontoparietal tracks and with larger gray-matter volume of right inferior parietal lobule. These findings demonstrate the importance of structural integrity and FC in working memory performance associated with healthy aging.
AB - The relations among structural integrity, functional connectivity (FC), and cognitive performance in the aging brain are still understudied. Here, we used multimodal and multivariate approaches to specifically examine age-related changes in task-related FC, gray-matter volumetrics, white-matter integrity, and performance. Our results are two-fold, showing (i) age-related differences in FC of the working memory network and (ii) age-related recruitment of a compensatory network associated with better accuracy on the task. Increased connectivity in the compensatory network correlates positively with preserved white-matter integrity in bilateral frontoparietal tracks and with larger gray-matter volume of right inferior parietal lobule. These findings demonstrate the importance of structural integrity and FC in working memory performance associated with healthy aging.
KW - Age-related compensation
KW - Functional connectivity
KW - Gray matter
KW - Structural integrity
KW - White matter
UR - http://www.scopus.com/inward/record.url?scp=84940962330&partnerID=8YFLogxK
UR - http://purl.org/au-research/grants/arc/DE130101290
U2 - 10.1016/j.neurobiolaging.2015.07.006
DO - 10.1016/j.neurobiolaging.2015.07.006
M3 - Article
C2 - 26234754
AN - SCOPUS:84940962330
SN - 0197-4580
VL - 36
SP - 2830
EP - 2837
JO - Neurobiology of Aging
JF - Neurobiology of Aging
IS - 10
ER -