TY - JOUR
T1 - The relationship between executive functions and fluid intelligence in euthymic Bipolar Disorder patients
AU - Goitia, Belén
AU - Manes, Facundo
AU - Torralva, Teresa
AU - Sigman, Mariano
AU - Duncan, John
AU - Cetkovich, Marcelo
AU - Roca, María
PY - 2017/11/1
Y1 - 2017/11/1
N2 - Distinct cognitive deficits have been described in Bipolar disorder (BD), including executive impairments, commonly attributed to frontal dysfunction. However, recent attention has been paid to the heterogeneity of cognitive functioning in this population, suggesting that the executive deficits observed in BD might be due to a loss in fluid intelligence (g). Following our previous line of investigation in multiple neurological and psychiatric conditions we aimed at determining the role of g in frontal deficits in BD. Euthymic BD patients (n = 51) and healthy controls (n = 37) were assessed with Wisconsin Card Sorting Test (WCST), Verbal Fluency, Trail Making Test B (TMTB), a multitasking test, and a theory of mind test. A general cognitive battery was used to derive a measure of g. As in other neuropsychiatric conditions, significant patient-control differences in WCST, Verbal Fluency and TMTB were removed when g was introduced as a covariate. Deficits remained significant in the multitasking test. We suggest that neuropsychological assessment in BD should include tests of general intelligence, together with one or more specific tasks that allow for the assessment of residual frontal deficits, putatively associated with anterior frontal functioning.
AB - Distinct cognitive deficits have been described in Bipolar disorder (BD), including executive impairments, commonly attributed to frontal dysfunction. However, recent attention has been paid to the heterogeneity of cognitive functioning in this population, suggesting that the executive deficits observed in BD might be due to a loss in fluid intelligence (g). Following our previous line of investigation in multiple neurological and psychiatric conditions we aimed at determining the role of g in frontal deficits in BD. Euthymic BD patients (n = 51) and healthy controls (n = 37) were assessed with Wisconsin Card Sorting Test (WCST), Verbal Fluency, Trail Making Test B (TMTB), a multitasking test, and a theory of mind test. A general cognitive battery was used to derive a measure of g. As in other neuropsychiatric conditions, significant patient-control differences in WCST, Verbal Fluency and TMTB were removed when g was introduced as a covariate. Deficits remained significant in the multitasking test. We suggest that neuropsychological assessment in BD should include tests of general intelligence, together with one or more specific tasks that allow for the assessment of residual frontal deficits, putatively associated with anterior frontal functioning.
KW - Spearman's g
KW - frontal deficits
KW - multitasking
KW - theory of mind
UR - http://www.scopus.com/inward/record.url?scp=85026898433&partnerID=8YFLogxK
U2 - 10.1016/j.psychres.2017.07.066
DO - 10.1016/j.psychres.2017.07.066
M3 - Article
C2 - 28800514
AN - SCOPUS:85026898433
VL - 257
SP - 346
EP - 351
JO - Psychiatry Research
JF - Psychiatry Research
SN - 0165-1781
ER -