The relationship between extra-coronary calcification and coronary artery lesion characteristics

S. Abeid, C. Yu, K. Ho-Shon, J. Magnussen, A. Yong, C. Naoum

    Research output: Contribution to journalMeeting abstractpeer-review


    Background: Calcifications in non–coronary cardiac and vascular locations are frequently observed in imaging modalities, including echocardiography and non–cardiac computed tomography (CT) scans. Previous studies have shown an association between extra-coronary calcification and risk factors of cardiovascular disease. This study aims to investigate the prevalence of extra-coronary calcification, and explore the association with coronary disease severity and plaque characteristics. Method: In total, 200 consecutive patients who underwent CT coronary angiography at our institution had coronary calcium score and lesion characteristics assessed by two experienced Level B readers. The CT scans were reviewed by a third blinded reader to measure the calcium score at four extra-coronary sites including the aortic valve, mitral annulus, and ascending and descending aorta. Results: The prevalence of extra-coronary calcification at any site was 53%. The prevalence of aortic valve, mitral annulus, and ascending and descending aorta calcification were 36.5%, 12%, 9%, and 35.5%, respectively. Patients with extra-coronary calcium score (ECCS) >0 had a higher prevalence of coronary calcification than patients without extra-coronary calcification (42% vs 16.5%; p < 0.001). Extra-coronary calcium score correlated with coronary calcium score ( r = 0.520; p < 0.001) and age ( r = 0.632; p < 0.001). Patients with extra-coronary calcification were more likely to have calcified plaques than patients with no extra-coronary calcification (67.9% vs 27.2%; p < 0.001). Patients with ECCS >400 had higher rates of significant coronary stenosis (>50% stenosis in ≥1 artery) than patients with ECCS ≤400 (55% vs 13.8%; p < 0.001). Conclusion : An ECCS>400 was associated with the presence of significant coronary disease. The clinical relevance of extra-coronary calcification in non–coronary imaging modalities warrants further investigation
    Original languageEnglish
    Article number0530
    Pages (from-to)S281-S282
    Number of pages2
    JournalHeart, Lung and Circulation
    Issue numberSupplement 2
    Publication statusPublished - 2018
    Event66th Cardiac Society of Australia and New Zealand Annual Scientific Meeting, the International Society for Heart Research Australasian Section Annual Scientific Meeting and the 12th Annual Australia and New Zealand Endovascular Therapies Meeting - Brisbane, Australia
    Duration: 2 Aug 20185 Aug 2018


    Dive into the research topics of 'The relationship between extra-coronary calcification and coronary artery lesion characteristics'. Together they form a unique fingerprint.

    Cite this