The relationship between midlife dyslipidemia and lifetime incidence of dementia: a systematic review and meta-analysis of cohort studies

Jason Wee; Sara Sukudom; Saiuj Bhat; Matti Marklund; Niridu Jude Peiris; Camilla M. Hoyos; Sanjay Patel; Sharon L. Naismith; Girish Dwivedi; Ashish Misra

doi:10.1002/dad2.12395

The relationship between midlife dyslipidemia and lifetime incidence of dementia: a systematic review and meta-analysis of cohort studies

Jason Wee, Sara Sukudom, Saiuj Bhat, Matti Marklund, Niridu Jude Peiris, Camilla M. Hoyos, Sanjay Patel, Sharon L. Naismith, Girish Dwivedi, Ashish Misra^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

45 Citations (Scopus)

22 Downloads (Pure)

Abstract

Introduction: We conducted a systematic review and meta-analysis to review the relationship between midlife dyslipidemia and lifetime incident dementia. Methods: The databases Medline, Embase, Scopus, Web of Science, and Cochrane were searched from inception to February 20, 2022. Longitudinal studies examining the relationship between midlife lipid levels on dementia, dementia subtypes, and/or cognitive impairment were pooled using inverse-variance weighted random-effects meta-analysis. Results: Seventeen studies (1.2 million participants) were included. Midlife hypercholesterolemia was associated with increased incidence of mild cognitive impairment (effect size [ES] = 2.01; 95% confidence interval [CI] 1.19 to 2.84; I² = 0.0%) and all-cause dementia (ES = 1.14; 95% CI: 1.07 to 1.21; I² = 0.0%). Each 1 mmol/L increase in low-density lipoprotein was associated with an 8% increase (ES = 1.08, 95% CI: 1.03 to 1.14; I² = 0.3%) in incidence of all-cause dementia. Discussion: Midlife dyslipidemia is associated with an increased risk of cognitive impairment in later life.

Original language	English
Article number	e12395
Pages (from-to)	1-11
Number of pages	11
Journal	Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume	15
Issue number	1
DOIs	https://doi.org/10.1002/dad2.12395
Publication status	Published - 1 Jan 2023
Externally published	Yes

Bibliographical note

Copyright the Author(s) 2022. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

aging
cholesterol
cognitive
cognitive dysfunction
dementia
dyslipidemia
midlife

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Wee, J., Sukudom, S., Bhat, S., Marklund, M., Peiris, N. J., Hoyos, C. M., Patel, S., Naismith, S. L., Dwivedi, G., & Misra, A. (2023). The relationship between midlife dyslipidemia and lifetime incidence of dementia: a systematic review and meta-analysis of cohort studies. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 15(1), 1-11. Article e12395. https://doi.org/10.1002/dad2.12395

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abstract = "Introduction: We conducted a systematic review and meta-analysis to review the relationship between midlife dyslipidemia and lifetime incident dementia. Methods: The databases Medline, Embase, Scopus, Web of Science, and Cochrane were searched from inception to February 20, 2022. Longitudinal studies examining the relationship between midlife lipid levels on dementia, dementia subtypes, and/or cognitive impairment were pooled using inverse-variance weighted random-effects meta-analysis. Results: Seventeen studies (1.2 million participants) were included. Midlife hypercholesterolemia was associated with increased incidence of mild cognitive impairment (effect size [ES] = 2.01; 95% confidence interval [CI] 1.19 to 2.84; I2 = 0.0%) and all-cause dementia (ES = 1.14; 95% CI: 1.07 to 1.21; I2 = 0.0%). Each 1 mmol/L increase in low-density lipoprotein was associated with an 8% increase (ES = 1.08, 95% CI: 1.03 to 1.14; I2 = 0.3%) in incidence of all-cause dementia. Discussion: Midlife dyslipidemia is associated with an increased risk of cognitive impairment in later life.",

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year = "2023",

month = jan,

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Wee, J, Sukudom, S, Bhat, S, Marklund, M, Peiris, NJ, Hoyos, CM, Patel, S, Naismith, SL, Dwivedi, G & Misra, A 2023, 'The relationship between midlife dyslipidemia and lifetime incidence of dementia: a systematic review and meta-analysis of cohort studies', Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, vol. 15, no. 1, e12395, pp. 1-11. https://doi.org/10.1002/dad2.12395

The relationship between midlife dyslipidemia and lifetime incidence of dementia: a systematic review and meta-analysis of cohort studies. / Wee, Jason; Sukudom, Sara; Bhat, Saiuj et al.
In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, Vol. 15, No. 1, e12395, 01.01.2023, p. 1-11.

Research output: Contribution to journal › Review article › peer-review

TY - JOUR

T1 - The relationship between midlife dyslipidemia and lifetime incidence of dementia

T2 - a systematic review and meta-analysis of cohort studies

AU - Wee, Jason

AU - Sukudom, Sara

AU - Bhat, Saiuj

AU - Marklund, Matti

AU - Peiris, Niridu Jude

AU - Hoyos, Camilla M.

AU - Patel, Sanjay

AU - Naismith, Sharon L.

AU - Dwivedi, Girish

AU - Misra, Ashish

N1 - Copyright the Author(s) 2022. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2023/1/1

Y1 - 2023/1/1

N2 - Introduction: We conducted a systematic review and meta-analysis to review the relationship between midlife dyslipidemia and lifetime incident dementia. Methods: The databases Medline, Embase, Scopus, Web of Science, and Cochrane were searched from inception to February 20, 2022. Longitudinal studies examining the relationship between midlife lipid levels on dementia, dementia subtypes, and/or cognitive impairment were pooled using inverse-variance weighted random-effects meta-analysis. Results: Seventeen studies (1.2 million participants) were included. Midlife hypercholesterolemia was associated with increased incidence of mild cognitive impairment (effect size [ES] = 2.01; 95% confidence interval [CI] 1.19 to 2.84; I2 = 0.0%) and all-cause dementia (ES = 1.14; 95% CI: 1.07 to 1.21; I2 = 0.0%). Each 1 mmol/L increase in low-density lipoprotein was associated with an 8% increase (ES = 1.08, 95% CI: 1.03 to 1.14; I2 = 0.3%) in incidence of all-cause dementia. Discussion: Midlife dyslipidemia is associated with an increased risk of cognitive impairment in later life.

AB - Introduction: We conducted a systematic review and meta-analysis to review the relationship between midlife dyslipidemia and lifetime incident dementia. Methods: The databases Medline, Embase, Scopus, Web of Science, and Cochrane were searched from inception to February 20, 2022. Longitudinal studies examining the relationship between midlife lipid levels on dementia, dementia subtypes, and/or cognitive impairment were pooled using inverse-variance weighted random-effects meta-analysis. Results: Seventeen studies (1.2 million participants) were included. Midlife hypercholesterolemia was associated with increased incidence of mild cognitive impairment (effect size [ES] = 2.01; 95% confidence interval [CI] 1.19 to 2.84; I2 = 0.0%) and all-cause dementia (ES = 1.14; 95% CI: 1.07 to 1.21; I2 = 0.0%). Each 1 mmol/L increase in low-density lipoprotein was associated with an 8% increase (ES = 1.08, 95% CI: 1.03 to 1.14; I2 = 0.3%) in incidence of all-cause dementia. Discussion: Midlife dyslipidemia is associated with an increased risk of cognitive impairment in later life.

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KW - cognitive

KW - cognitive dysfunction

KW - dementia

KW - dyslipidemia

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JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

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ER -

The relationship between midlife dyslipidemia and lifetime incidence of dementia: a systematic review and meta-analysis of cohort studies

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