The relative contributions of psychiatric symptoms and psychotropic medications on the sleep-wake profile of young persons with anxiety, depression and bipolar disorders

Rébecca Robillard, Cristal Oxley, Daniel F. Hermens, Django White, Ryan Wallis, Sharon L. Naismith, Bradley Whitwell, James Southan, Elizabeth M. Scott, Ian B. Hickie*

*Corresponding author for this work

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

This study investigated the relative contribution of psychiatric symptoms and psychotropic medications on the sleep-wake cycle. Actigraphy and clinical assessments (Brief Psychiatric Rating Scale) were conducted in 146 youths with anxiety, depression or bipolar disorders. Independently of medications, mania symptoms were predictive of lower circadian amplitude and rhythmicity. Independently of diagnosis and symptoms severity: i) antipsychotics were related to longer sleep period and duration, ii) serotonin-norepinephrine reuptake inhibitors to longer sleep period, and iii) agomelatine to earlier sleep onset. Manic symptoms and different subclasses of medications may have independent influences on the sleep-wake cycle of young people with mental disorders.

Original languageEnglish
Pages (from-to)403-406
Number of pages4
JournalPsychiatry Research
Volume243
DOIs
Publication statusPublished - 30 Sep 2016
Externally publishedYes

Keywords

  • Actigraphy
  • Affective disorders
  • Pharmacotherapy

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