The reporting of anal cytology and histology samples: establishing terminology and criteria

Jennifer Margaret Roberts*, Deborah Ekman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Our understanding of the human papillomavirus (HPV) related cytomorphology and histopathology of the anal canal is underpinned by our knowledge of HPV infection in the cervix. In this review, we utilise cervical reporting of cytological and histological specimens as a foundation for the development of standardised and evidence-based terminology and criteria for reporting of anal specimens. We advocate use of the Australian Modified Bethesda System 2004 for reporting anal cytology. We propose the use of a two-tiered histological reporting system for noninvasive disease - low-grade and high-grade anal intraepithelial neoplasia. These classification systems reflect current understanding of the biology of HPV and enhance diagnostic reproducibility. Biomarkers such as p16(INK4A) may prove useful in further improving diagnostic accuracy. Standardisation is important because it will increase the value of the data collected as Australian centres develop programs for screening for anal neoplasia.

Original languageEnglish
Pages (from-to)562-567
Number of pages6
JournalSexual Health
Volume9
Issue number6
DOIs
Publication statusPublished - 25 May 2012
Externally publishedYes

Keywords

  • anal canal
  • anal intraepithelial neoplasia
  • Australian Modified Bethesda System
  • human papillomavirus
  • liquid-based cytology
  • HIGH-RESOLUTION ANOSCOPY
  • DIAGNOSTIC SURGICAL PATHOLOGY
  • BETHESDA SYSTEM TERMINOLOGY
  • HIV-INFECTED PATIENTS
  • INTRAEPITHELIAL NEOPLASIA
  • HUMAN-PAPILLOMAVIRUS
  • ENDOCERVICAL STATUS
  • INTEROBSERVER AGREEMENT
  • CERVICAL SMEARS
  • RECTAL CYTOLOGY

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