The role of altered upper airway sensitivity in respiratory disease

evidence from human studies

Lorcan McGarvey*, Sin Y. Phua, Alvin J. Ing

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter


The upper airway is intricately involved in airway protection guarding against aspiration of noxious solid and liquid materials. The larynx and pharynx are exquisitely sensitive to mechanical and chemical stimuli which trigger protective reflexes resulting in a number of behavioural elements designed to prevent aspiration including coughing, swallowing, vocal cord adduction and suppression of respiration. Depression or exaggeration of these reflexes result in clinical problems and recent improvement in methods designed to assess laryngopharyngeal sensation in humans has added greatly to our knowledge of these airway reflexes in both health and disease.

Original languageEnglish
Title of host publicationEffects, diagnosis and management of extra-esophageal reflux
EditorsNikki Johnston, Robert J. Toohill
Place of PublicationNew york
PublisherNova Science Publishers
Number of pages13
ISBN (Print)9781621003441, 1621003442
Publication statusPublished - Jan 2012
Externally publishedYes

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