Abstract
There is increasing evidence suggesting that epoxyeicosatrienoic acids (EETs) play an important role in cardioprotective mechanisms. These include regulating vascular tone, modulating inflammatory responses, improving cardiomyocyte function and reducing ischaemic damage, resulting in attenuation of animal models of cardiovascular risk factors. This review discusses the current knowledge on the role of EETs in endothelium-dependent control of vascular tone in the healthy and in subjects with cardiovascular risk factors, and considers the pharmacological potential of targeting this pathway.
| Original language | English |
|---|---|
| Pages (from-to) | 28-44 |
| Number of pages | 17 |
| Journal | British Journal of Clinical Pharmacology |
| Volume | 80 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1 Jul 2015 |
| Externally published | Yes |
Bibliographical note
Copyright the Author(s) 2015. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.Keywords
- cardiovascular system
- epoxyeicosatrienoic acids
- soluble epoxide hydrolase inhibitor
- vascular tone