The role of epoxyeicosatrienoic acids in the cardiovascular system

L. Yang*, K. Mäki-Petäjä, J. Cheriyan, C. McEniery, I. B. Wilkinson

*Corresponding author for this work

Research output: Contribution to journalArticle

34 Citations (Scopus)
3 Downloads (Pure)

Abstract

There is increasing evidence suggesting that epoxyeicosatrienoic acids (EETs) play an important role in cardioprotective mechanisms. These include regulating vascular tone, modulating inflammatory responses, improving cardiomyocyte function and reducing ischaemic damage, resulting in attenuation of animal models of cardiovascular risk factors. This review discusses the current knowledge on the role of EETs in endothelium-dependent control of vascular tone in the healthy and in subjects with cardiovascular risk factors, and considers the pharmacological potential of targeting this pathway.

Original languageEnglish
Pages (from-to)28-44
Number of pages17
JournalBritish Journal of Clinical Pharmacology
Volume80
Issue number1
DOIs
Publication statusPublished - 1 Jul 2015
Externally publishedYes

Bibliographical note

Copyright the Author(s) 2015. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • cardiovascular system
  • epoxyeicosatrienoic acids
  • soluble epoxide hydrolase inhibitor
  • vascular tone

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