Rola proteolizy zewnątrzkomórkowej w plastyczności synaptycznej ośrodkowego układu nerwowego

Translated title of the contribution: The role of extracellular proteolysis in synaptic plasticity of the central nervous system

Klaudia Ziemiańska, Anna Konopka, Grzegorz M Wilczyński

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The extracellular matrix (ECM) of the central nervous system has a specific structure and protein composition that are different from those in other organs. Today we know that the ECM not only provides physical scaffolding for the neurons and glia, but also actively modifies their functions. Over the last two decades, a growing body of research evidence has been collected, suggesting an important role of ECM proteolysis in synaptic plasticity of the brain. So far the majority of data concern two large families of proteases: the serine proteases and the matrix metalloproteinases. The members of these families are localized at the synapses, and are secreted into the extracellular space in an activity-dependent manner. The proteases remodel the local environment as well as influencing synapse structure and function. The structural modifications induced by proteases include shape and size changes, as well as synapse elimination, and synaptogenesis. The functional changes include modifications of receptor function in the postsynaptic part of the synapse, as well as the potentiation or depression of neurotransmitter secretion by the presynaptic site. The present review summarizes the current view on the role of extracellular proteolysis in the physiological synaptic plasticity underlying the phenomena of learning and memory, as well as in the pathological plasticity occurring during epileptogenesis or development of drug addiction.

Original languagePolish
Pages (from-to)959-975
Number of pages17
JournalPostepy Higieny i Medycyny Doswiadczalnej
Volume66
Publication statusPublished - 29 Nov 2012
Externally publishedYes

Keywords

  • Brain
  • Epilepsy
  • Extracellular Matrix
  • Humans
  • Matrix Metalloproteinases
  • Neuroglia
  • Neuronal Plasticity
  • Neurons
  • Proteolysis
  • Serine Endopeptidases
  • Substance-Related Disorders
  • Synapses
  • Synaptic Transmission
  • English Abstract
  • Journal Article
  • Review

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