The role of Glypican-1 in the tumour microenvironment

Maria E. Lund, Douglas H. Campbell, Bradley J. Walsh

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Glypican-1 (GPC-1) is a cell surface heparan sulphate proteoglycan that is critical during normal development, but which is not required for normal homoeostasis in the adult. It is, however, overexpressed in a variety of solid tumours and is known to regulate tumour growth, invasion, metastasis and progression, through modulation of tumour cell biology as well as influence on the tumour microenvironment (TME). The role of GPC-1 in the TME and on the tumour cell is broad, as GPC-1 regulates signalling by several growth factors, including FGF, HGF, TGF-β, Wnt and Hedgehog (Hh). Signalling via these pathways promotes tumour growth and invasive and metastatic ability (drives epithelial-to-mesenchymal transition (EMT)) and influences angiogenesis, affecting both tumour and stromal cells. Broad modulation of the TME via inhibition of GPC-1 may represent a novel therapeutic strategy for inhibition of tumour progression. Here, we discuss the complex role of GPC-1 in tumour cells and the TME, with discussion of potential therapeutic targeting strategies.

Original languageEnglish
Title of host publicationTumor Microenvironment
Subtitle of host publicationExtracellular Matrix Components – Part A
EditorsAlexander Birbrair
Place of PublicationCham, Switzerland
PublisherSpringer, Springer Nature
Pages163-176
Number of pages14
ISBN (Electronic)9783030401467
ISBN (Print)9783030401450
DOIs
Publication statusPublished - 2020
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
PublisherSpringer, Springer Nature
Volume1245
ISSN (Print)0065-2598

Keywords

  • Angiogenesis
  • Glypican-1
  • GPC-1
  • Growth factor signalling
  • Invasion
  • Metastasis
  • Pancreatic cancer
  • Stroma
  • Therapeutics
  • Tumour microenvironment

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  • Cite this

    Lund, M. E., Campbell, D. H., & Walsh, B. J. (2020). The role of Glypican-1 in the tumour microenvironment. In A. Birbrair (Ed.), Tumor Microenvironment: Extracellular Matrix Components – Part A (pp. 163-176). (Advances in Experimental Medicine and Biology; Vol. 1245). Cham, Switzerland: Springer, Springer Nature. https://doi.org/10.1007/978-3-030-40146-7_8