The role of mesenchymal stem cells in veterinary therapeutics - a review

R. A. Webster, S. P. Blaber, B. R. Herbert, M. R. Wilkins, G. Vesey

    Research output: Contribution to journalReview articlepeer-review

    21 Citations (Scopus)

    Abstract

    Adult mammalian tissue contains a population of cells known as mesenchymal stem cells (MSC), that possess the capability to secrete regenerative cytokines and to differentiate into specialised cell types. When transplanted to a site of injury MSC embed in damaged tissue and repair and regenerate the tissue by secreting cytokines. The immuno-privileged and immuno-regulatory capabilities of MSC enhance their therapeutic potential not only in autologous but also allogeneic recipients. Studies have demonstrated the beneficial effects of MSC in the treatment of a variety of clinical conditions including osteoarthritis, tendon injuries, and atopic dermatitis in domestic animals. Studies using animal models have shown promising results following MSC or MSC secretion therapy for induced injury in musculoskeletal and nervous systems and some organ diseases.This review describes the stem cell types relevant to regenerative medicine and the procedures used for isolation, identification, expansion, enrichment and differentiation of these cells. We also review the use of MSC in animal models of disease as well as diseases in the clinical veterinary setting.

    Original languageEnglish
    Pages (from-to)265-272
    Number of pages8
    JournalNew Zealand Veterinary Journal
    Volume60
    Issue number5
    DOIs
    Publication statusPublished - Sep 2012

    Fingerprint

    Dive into the research topics of 'The role of mesenchymal stem cells in veterinary therapeutics - a review'. Together they form a unique fingerprint.

    Cite this