The role of polyphenols in the modulation of sirtuins and other pathways involved in Alzheimer's disease

T. Jayasena, A. Poljak, G. Smythe, N. Braidy, G. Münch, P. Sachdev*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

81 Citations (Scopus)

Abstract

Alzheimer's disease (AD) is characterised by extracellular amyloid deposits, neurofibrillary tangles, synaptic loss, inflammation and extensive oxidative stress. Polyphenols, which include resveratrol, epigallocatechin gallate and curcumin, have gained considerable interest for their ability to reduce these hallmarks of disease and their potential to slow down cognitive decline. Although their antioxidant and free radical scavenging properties are well established, more recently polyphenols have been shown to produce other important effects including anti-amyloidogenic activity, cell signalling modulation, effects on telomere length and modulation of the sirtuin proteins. Brain accessible polyphenols with multiple effects on pathways involved in neurodegeneration and ageing may therefore prove efficacious in the treatment of age-related diseases such as AD, although the evidence for this so far is limited. This review aims to explore the known effects of polyphenols from various natural and synthetic sources on brain ageing and neurodegeneration, and to examine their multiple mechanisms of action, with an emphasis on the role that the sirtuin pathway may play and the implications this may have for the treatment of AD.

Original languageEnglish
Pages (from-to)867-883
Number of pages17
JournalAgeing Research Reviews
Volume12
Issue number4
DOIs
Publication statusPublished - Sep 2013
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Phenolics
  • Polyphenol
  • Sirtuin

Fingerprint

Dive into the research topics of 'The role of polyphenols in the modulation of sirtuins and other pathways involved in Alzheimer's disease'. Together they form a unique fingerprint.

Cite this