Rola białek jako przekaźników uszkodzeń indukowanych przez reaktywne formy tlenu in vivo

Translated title of the contribution: [The role of proteins in propagation of damage induced by reactive oxygen species in vivo].

Janusz M. Gebicki*, Grzegorz Bartosz

*Corresponding author for this work

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Although the damaging effects of partially reduced oxygen species (PROS) in vivo have long been known, the mechanism of reactions responsible for their pathological effects is still not clear. Our review presents evidence supporting the thesis, that proteins are the primary targets of PROS in cells, and that the protein radicals and other reactive protein derivatives generated act as intermediates, propagating the oxidative damage to other cell components. Understanding of the reactions of reactive forms of proteins should result in more effective defence of organisms against the effects of oxidative stress.

Original languagePolish
Pages (from-to)115-123
Number of pages9
JournalPostepy biochemii
Volume56
Issue number2
Publication statusPublished - 2010

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