The role of reactive oxygen species in the pathogenesis and treatment of retinal diseases

Thomas CW. Chan; Jennifer L. Wilkinson Berka; Devy Deliyanti; Damien Hunter; Adrian Fung; Gerald Liew; Andrew White

doi:10.1016/j.exer.2020.108255

The role of reactive oxygen species in the pathogenesis and treatment of retinal diseases

Thomas CW. Chan, Jennifer L. Wilkinson Berka, Devy Deliyanti, Damien Hunter, Adrian Fung, Gerald Liew, Andrew White^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

47 Citations (Scopus)

Abstract

Reactive oxygen species (ROS) normally play an important physiological role in health regulating cellular processes and signal transduction. The amount of ROS is usually kept in fine balance with the generation of ROS largely being offset by the body's antioxidants. A tipping of this balance has increasingly been recognised as a contributor to human disease. The retina, as a result of its cellular anatomy and physical location, is a potent generator of ROS that has been linked to several major retinal diseases. This review will provide a summary of the role of oxidative stress in the pathogenesis of diabetic retinopathy, age-related macular degeneration, myopia, retinal vein occlusion, retinitis pigmentosa and retinopathy of prematurity. Therapies aimed at controlling oxidative stress in these diseases are also examined.

Original language	English
Article number	108255
Pages (from-to)	1-11
Number of pages	11
Journal	Experimental Eye Research
Volume	201
DOIs	https://doi.org/10.1016/j.exer.2020.108255
Publication status	Published - Dec 2020

Keywords

Oxidative stress
Pathogenesis
Reactive oxygen species
Retinal disease
Treatment

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10.1016/j.exer.2020.108255

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title = "The role of reactive oxygen species in the pathogenesis and treatment of retinal diseases",

abstract = "Reactive oxygen species (ROS) normally play an important physiological role in health regulating cellular processes and signal transduction. The amount of ROS is usually kept in fine balance with the generation of ROS largely being offset by the body's antioxidants. A tipping of this balance has increasingly been recognised as a contributor to human disease. The retina, as a result of its cellular anatomy and physical location, is a potent generator of ROS that has been linked to several major retinal diseases. This review will provide a summary of the role of oxidative stress in the pathogenesis of diabetic retinopathy, age-related macular degeneration, myopia, retinal vein occlusion, retinitis pigmentosa and retinopathy of prematurity. Therapies aimed at controlling oxidative stress in these diseases are also examined.",

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AU - Wilkinson Berka, Jennifer L.

AU - Deliyanti, Devy

AU - Hunter, Damien

AU - Fung, Adrian

AU - Liew, Gerald

AU - White, Andrew

PY - 2020/12

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KW - Treatment

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The role of reactive oxygen species in the pathogenesis and treatment of retinal diseases

Abstract

Keywords

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