The role of reactive oxygen species in the pathogenesis and treatment of retinal diseases

Thomas CW. Chan, Jennifer L. Wilkinson Berka, Devy Deliyanti, Damien Hunter, Adrian Fung, Gerald Liew, Andrew White*

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    22 Citations (Scopus)

    Abstract

    Reactive oxygen species (ROS) normally play an important physiological role in health regulating cellular processes and signal transduction. The amount of ROS is usually kept in fine balance with the generation of ROS largely being offset by the body's antioxidants. A tipping of this balance has increasingly been recognised as a contributor to human disease. The retina, as a result of its cellular anatomy and physical location, is a potent generator of ROS that has been linked to several major retinal diseases. This review will provide a summary of the role of oxidative stress in the pathogenesis of diabetic retinopathy, age-related macular degeneration, myopia, retinal vein occlusion, retinitis pigmentosa and retinopathy of prematurity. Therapies aimed at controlling oxidative stress in these diseases are also examined.

    Original languageEnglish
    Article number108255
    Pages (from-to)1-11
    Number of pages11
    JournalExperimental Eye Research
    Volume201
    DOIs
    Publication statusPublished - Dec 2020

    Keywords

    • Oxidative stress
    • Pathogenesis
    • Reactive oxygen species
    • Retinal disease
    • Treatment

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