The siRNAsome

a cation free and versatile nanostructure for siRNA and drug codelivery

Meng Zheng, Tong Jiang, Wen Yang, Yan Zou, Haigang Wu, Xiuhua Liu, Kerrie McDonald, Daishun Ling, Jinjun Shi, Fengping Zhu, Rongjun Qian, Bingyang Shi*

*Corresponding author for this work

Research output: Contribution to journalArticle

17 Citations (Scopus)
11 Downloads (Pure)

Abstract

Nanoparticles show great potential for drug delivery. However, suitable nanostructures capable of loading a range of drugs together with the co-delivery of siRNAs, which avoid the problem of cation-associated cytotoxicity, are lacking. Herein, we report an small interfering RNA (siRNA)-based vesicle (siRNAsome), which consists of a hydrophilic siRNA shell, a thermal- and intracellular-reduction-sensitive hydrophobic median layer, and an empty aqueous interior that meets this need. The siRNAsome can serve as a versatile nanostructure to load drug agents with divergent chemical properties, therapeutic proteins as well as co-delivering immobilized siRNAs without transfection agents. Importantly, the inherent thermal/reduction-responsiveness enables controlled drug loading and release. When siRNAsomes are loaded with the hydrophilic drug doxorubicin hydrochloride and anti-P-glycoprotein siRNA, synergistic therapeutic activity is achieved in multidrug resistant cancer cells and a tumor model.

Original languageEnglish
Pages (from-to)4938-4942
Number of pages5
JournalAngewandte Chemie - International Edition
Volume58
Issue number15
DOIs
Publication statusPublished - 1 Apr 2019

Bibliographical note

Copyright the Author(s) 2019. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • co-delivery
  • nanostructures
  • siRNA
  • synergistic therapy
  • vesicles

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