The siRNAsome: a cation free and versatile nanostructure for siRNA and drug codelivery

Meng Zheng, Tong Jiang, Wen Yang, Yan Zou, Haigang Wu, Xiuhua Liu, Kerrie McDonald, Daishun Ling, Jinjun Shi, Fengping Zhu, Rongjun Qian, Bingyang Shi*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    38 Citations (Scopus)
    84 Downloads (Pure)

    Abstract

    Nanoparticles show great potential for drug delivery. However, suitable nanostructures capable of loading a range of drugs together with the co-delivery of siRNAs, which avoid the problem of cation-associated cytotoxicity, are lacking. Herein, we report an small interfering RNA (siRNA)-based vesicle (siRNAsome), which consists of a hydrophilic siRNA shell, a thermal- and intracellular-reduction-sensitive hydrophobic median layer, and an empty aqueous interior that meets this need. The siRNAsome can serve as a versatile nanostructure to load drug agents with divergent chemical properties, therapeutic proteins as well as co-delivering immobilized siRNAs without transfection agents. Importantly, the inherent thermal/reduction-responsiveness enables controlled drug loading and release. When siRNAsomes are loaded with the hydrophilic drug doxorubicin hydrochloride and anti-P-glycoprotein siRNA, synergistic therapeutic activity is achieved in multidrug resistant cancer cells and a tumor model.

    Original languageEnglish
    Pages (from-to)4938-4942
    Number of pages5
    JournalAngewandte Chemie - International Edition
    Volume58
    Issue number15
    DOIs
    Publication statusPublished - 1 Apr 2019

    Bibliographical note

    Copyright the Author(s) 2019. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

    Keywords

    • co-delivery
    • nanostructures
    • siRNA
    • synergistic therapy
    • vesicles

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