The SPICE III study protocol and analysis plan: a randomised trial of early goaldirected sedation compared with standard care in mechanically ventilated patients

Yahya Shehabi, Andrew B. Forbes, Yaseen Arabi, Frances Bass, Rinaldo Bellomo, Suhaini Kadiman, Belinda D. Howe, Colin McArthur, Michael C. Reade, Ian Seppelt, Jukka Takala, Steve Webb, Matthew P. Wise, The SPICE III study investigators , The Australian and New Zealand Intensive Care Society Clinical Trials Group , The Australian and New Zealand Intensive Care Research Centre

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