The strategies of nanomaterials for traversing blood-brain barrier

Mohd Ahmar Rauf, Fawad Ur Rehman, Meng Zheng, Bingyang Shi

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Central nervous system (CNS) ailments establish an arrangement of difficult neurotic conditions concerning identification and therapeutics. For the more significant part of these clusters, there is an absence of an early determination, biomarkers to permit legitimate follow-up of infection movement and powerful, effective methodologies to permit a diligent fix.

The engraved prognosis and diagnosis of neurodegenerative disease at advanced stages and in older people are recognized as serious health concern worldwide, especially interminable age-related neurodegenerative malfunctions that are reflected as general well-being issues.

The principal issue related to the management of CNS infections is owed, in any event to some degree, to specific qualities of the brain and spinal cord, when contrasted with peripheral organs. In such manner, the CNS is physically and synthetically secured by the blood-brain barrier (BBB) that is responsible for the maintenance of brain’s homeostasis and substantially limits the movement of most therapeutics to the brain parenchyma. Different methodologies for the therapeutics were developed and modified for transposing the BBB and expecting to treat brain disorders, without meddling with the regular functioning of the brain.

In the present chapter, we will try to harness the most recent advances in neurodegenerative diseases amelioration approaches based on distinctive drug delivery systems via nanoscale materials, exosomes, and RNAi (i.e., siRNA, etc.) based frameworks.
Original languageEnglish
Title of host publicationNanomedicine in brain diseases
Subtitle of host publicationprinciples and application
EditorsXue Xue
Place of PublicationSingapore
PublisherSpringer, Springer Nature
Number of pages29
ISBN (Electronic)9789811387319
ISBN (Print)9789811387302
Publication statusPublished - 8 Nov 2019
Externally publishedYes


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