The upside of downsizing

asymmetric trifunctional organocatalysts as small enzyme mimics for cooperative enhancement of both rate and enantioselectivity with regulation

Fei Liu*

*Corresponding author for this work

Research output: Contribution to journalReview article

12 Citations (Scopus)
19 Downloads (Pure)

Abstract

Small molecule organic catalysts (organocatalysts) are widely used in asymmetric catalysis and synthesis. Compared to their enzymatic and transition-metal counterparts, organocatalysts have advantages in catalytic scope and efficiency but are more limited in proficiency. Chiral trifunctional organocatalysts, in which multiple catalytic motifs act cooperatively on a chiral scaffold, are an emerging class of organocatalysts with improved proficiency. Cooperativity design that enables both enantioselectivity and rate enhancement is essential to developing future generations of organocatalysts in biomimetic asymmetric catalysis. Chirality 25:675-683, 2013.

Original languageEnglish
Pages (from-to)675-683
Number of pages9
JournalChirality
Volume25
Issue number11
DOIs
Publication statusPublished - Nov 2013

Keywords

  • multifunctional organocatalysts
  • catalytic proficiency
  • REAP factor
  • enantioselective activation
  • proton transfer
  • organocatalysis regulation
  • catalytic assembly

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