The use of benzodiazepines for tinnitus: systematic review

N. E. Jufas*, R. Wood

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Objectives: To investigate the effectiveness of benzodiazepine use for subjective tinnitus and to consider this in the context of the concomitant side effects. Methods: A systematic search of several databases using the terms 'tinnitus' and 'benzodiazepines' was conducted to find clinical trials of benzodiazepines and comparators in tinnitus patients. These studies were then assessed for risk of bias. Results: Six clinical trials were included. Clonazepam was found to be effective in three studies, but these studies had limitations regarding adequate blinding. The effectiveness of alprazolam was equivocal. Diazepam was not effective in two studies and oxazepam was effective in one study. Conclusion: Benzodiazepine use for subjective tinnitus does not have a robust evidence base. Clonazepam has the most evidence to support its use and is relatively less likely to lead to abuse because of its longer half-life, but caution is still needed given the other serious side effects.

Original languageEnglish
Pages (from-to)S14-S22
Number of pages9
JournalJournal of Laryngology and Otology
Volume129
Issue numberS3
DOIs
Publication statusPublished - 8 Jul 2015
Externally publishedYes

Keywords

  • Benzodiazepines
  • Review
  • Tinnitus

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