The use of computational approaches in inhaler development

William Wong, David F. Fletcher, Daniela Traini, Hak-Kim Chan, Paul M. Young

Research output: Contribution to journalArticlepeer-review

48 Citations (Scopus)

Abstract

Computational Fluid Dynamics (CFD) and Discrete Element Modelling (DEM) studies relevant to inhaled drug delivery are reviewed. CFD is widely used in device design to determine airflow patterns and turbulence levels. CFD is also used to simulate particles and droplets, which are subjected to various forces, turbulence and wall interactions. These studies can now be performed routinely because of the availability of commercial software containing high quality turbulence and particle models.

DEM allows for the modelling of agglomerate break-up upon interaction with a wall or due to shear in the flow. However, the computational cost is high and the number of particles that can be simulated is minimal compared with the number present in typical inhaled formulations. Therefore DEM is currently limited to fundamental studies of break-up mechanisms.

With decreasing computational limitations, simulations combining CFD and DEM that can address outstanding issues in agglomerate break-up and dispersion will be possible.
Original languageEnglish
Pages (from-to)312-322
Number of pages11
JournalAdvanced Drug Delivery Reviews
Volume64
Issue number4
DOIs
Publication statusPublished - 2012
Externally publishedYes

Keywords

  • Computational Fluid Dynamics (CFD)
  • Discrete Element Modelling (DEM)
  • Particle behaviour
  • Deagglomeration
  • Dry powder inhaler (DPI)
  • Pressurised metered dose inhaler (pMDI)
  • Nebulizer

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