The use of organic vapor sorption to determine low levels of amorphous content in processed pharmaceutical powders

Paul M. Young, Herbert Chiou, Terrance Tee, Daniela Traini, Hak-Kim Chan, Frank Thielmann, Dan Burnett

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)

Abstract

Organic dynamic vapor sorption (organic-DVS) was used to characterize amorphous content in known amorphous-crystalline mixtures of lactose and salbutamol sulfate. N-octane was chosen as an apolar probe and measurements were carried out by exposing mixtures of each sample to partial pressures 0–90% p/p0. A linear relationship between amorphous content and n-octane partial pressure was observed for both lactose and salbutamol sulfate with R2 values of 0.992 and 0.999, respectively. In addition, the influence of sequential mechanical processing in a ball mill on the amorphous content in crystalline lactose was investigated. Cumulative milling times resulted in an exponential increase in amorphous content (using the linear relationship obtained for lactose), with a maximum amorphous content of 14% being induced after 60 min milling. In comparison, analysis of the 60 min mill time samples after exposure to 85% relative humidity suggested 0.00% amorphous content.
Original languageEnglish
Pages (from-to)91-97
Number of pages7
JournalDrug Development and Industrial Pharmacy
Volume33
Issue number1
DOIs
Publication statusPublished - 2007
Externally publishedYes

Keywords

  • Lactose
  • Salbutamol sulfate
  • Amorphous
  • Ball milling
  • Organic dynamic vapor sorption

Fingerprint

Dive into the research topics of 'The use of organic vapor sorption to determine low levels of amorphous content in processed pharmaceutical powders'. Together they form a unique fingerprint.

Cite this