The voices of stakeholders involved in precision medicine: the co-design and evaluation of qualitative indicators of intervention acceptability, fidelity, and context in PRecISion Medicine for Children with Cancer in Australia

James Smith; Jeffrey Braithwaite; Tracey A. O'Brien; Stephanie  Smith; Vanessa J. Tyrell; Emily V. A. Mould; Janet C. Long; Frances Rapport

doi:10.1177/10497323221120501

The voices of stakeholders involved in precision medicine: the co-design and evaluation of qualitative indicators of intervention acceptability, fidelity, and context in PRecISion Medicine for Children with Cancer in Australia

James Smith, Jeffrey Braithwaite, Tracey A. O'Brien, Stephanie Smith, Vanessa J. Tyrell, Emily V. A. Mould, Janet C. Long, Frances Rapport

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

We report a novel approach of amalgamating implementation outcomes of acceptability and fidelity alongside context as a new way of qualitatively evaluating implementation outcomes and context of a precision medicine intervention. A rapid qualitative online proforma was co-designed with stakeholders and sent to a purposive sample of healthcare professionals involved in an early-phase clinical trial intervention. Data were analysed using Framework Analysis. A total of 24 out of 68 proformas were returned. Although some participants raised concerns about drug medication access issues, the main intervention was well accepted and understood across professional groups. Comprehension was enhanced through exposure to specialist multidisciplinary meeting arrangements. In conclusion, a rapid data collection tool and framework are now available to assess readily measurable, qualitative indicators of acceptability, fidelity of receipt and contextual fit within the dynamic precision medicine context.

Original language	English
Pages (from-to)	1865-1880
Number of pages	16
Journal	Qualitative Health Research
Volume	32
Issue number	12
Early online date	6 Sept 2022
DOIs	https://doi.org/10.1177/10497323221120501
Publication status	Published - Oct 2022

Keywords

behaviour change
behaviour
cancer
complexity
qualitative

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Centre for Research Excellence in Implementation Science in Oncology (CRE-ISO)
Braithwaite, J., Ward, R., Currow, D., Delaney, G., Kefford, R., Olver, I., Karnon, J., Crowe, P., Liauw, W., Westbrook, J., Meiser, B., Tieman, J., Verspoor, K., Ellis, L., Krishnasamy, M., Ayliff, N., Hawkins, N., Hibbert, P., Farnsworth, R. & Clay-Williams, R.
1/12/17 → 30/11/22
Project: Other
NHMRC Partnership Centre on Health System Sustainability
Braithwaite, J., Ward, R., Anderson, T., Teede, H., Wells, L., Gray, L., Yeend, T., Coiera, E., Westbrook, J., Glasziou, P., Scott, A., Karnon, J. & Buchbinder, R.
1/07/17 → 31/12/22
Project: Research

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Smith, J., Braithwaite, J., O'Brien, T. A., Smith, S., Tyrell, V. J., Mould, E. V. A., Long, J. C., & Rapport, F. (2022). The voices of stakeholders involved in precision medicine: the co-design and evaluation of qualitative indicators of intervention acceptability, fidelity, and context in PRecISion Medicine for Children with Cancer in Australia. Qualitative Health Research, 32(12), 1865-1880. https://doi.org/10.1177/10497323221120501

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abstract = "We report a novel approach of amalgamating implementation outcomes of acceptability and fidelity alongside context as a new way of qualitatively evaluating implementation outcomes and context of a precision medicine intervention. A rapid qualitative online proforma was co-designed with stakeholders and sent to a purposive sample of healthcare professionals involved in an early-phase clinical trial intervention. Data were analysed using Framework Analysis. A total of 24 out of 68 proformas were returned. Although some participants raised concerns about drug medication access issues, the main intervention was well accepted and understood across professional groups. Comprehension was enhanced through exposure to specialist multidisciplinary meeting arrangements. In conclusion, a rapid data collection tool and framework are now available to assess readily measurable, qualitative indicators of acceptability, fidelity of receipt and contextual fit within the dynamic precision medicine context.",

keywords = "behaviour change, behaviour, cancer, complexity, qualitative",

author = "James Smith and Jeffrey Braithwaite and O'Brien, {Tracey A.} and Stephanie Smith and Tyrell, {Vanessa J.} and Mould, {Emily V. A.} and Long, {Janet C.} and Frances Rapport",

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Smith, J, Braithwaite, J, O'Brien, TA, Smith, S, Tyrell, VJ, Mould, EVA, Long, JC & Rapport, F 2022, 'The voices of stakeholders involved in precision medicine: the co-design and evaluation of qualitative indicators of intervention acceptability, fidelity, and context in PRecISion Medicine for Children with Cancer in Australia', Qualitative Health Research, vol. 32, no. 12, pp. 1865-1880. https://doi.org/10.1177/10497323221120501

The voices of stakeholders involved in precision medicine: the co-design and evaluation of qualitative indicators of intervention acceptability, fidelity, and context in PRecISion Medicine for Children with Cancer in Australia. / Smith, James; Braithwaite, Jeffrey; O'Brien, Tracey A. et al.
In: Qualitative Health Research, Vol. 32, No. 12, 10.2022, p. 1865-1880.

Research output: Contribution to journal › Article › peer-review

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T2 - the co-design and evaluation of qualitative indicators of intervention acceptability, fidelity, and context in PRecISion Medicine for Children with Cancer in Australia

AU - Smith, James

AU - Braithwaite, Jeffrey

AU - O'Brien, Tracey A.

AU - Smith, Stephanie

AU - Tyrell, Vanessa J.

AU - Mould, Emily V. A.

AU - Long, Janet C.

AU - Rapport, Frances

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AB - We report a novel approach of amalgamating implementation outcomes of acceptability and fidelity alongside context as a new way of qualitatively evaluating implementation outcomes and context of a precision medicine intervention. A rapid qualitative online proforma was co-designed with stakeholders and sent to a purposive sample of healthcare professionals involved in an early-phase clinical trial intervention. Data were analysed using Framework Analysis. A total of 24 out of 68 proformas were returned. Although some participants raised concerns about drug medication access issues, the main intervention was well accepted and understood across professional groups. Comprehension was enhanced through exposure to specialist multidisciplinary meeting arrangements. In conclusion, a rapid data collection tool and framework are now available to assess readily measurable, qualitative indicators of acceptability, fidelity of receipt and contextual fit within the dynamic precision medicine context.

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Smith J, Braithwaite J, O'Brien TA, Smith S, Tyrell VJ, Mould EVA et al. The voices of stakeholders involved in precision medicine: the co-design and evaluation of qualitative indicators of intervention acceptability, fidelity, and context in PRecISion Medicine for Children with Cancer in Australia. Qualitative Health Research. 2022 Oct;32(12):1865-1880. Epub 2022 Sept 6. doi: 10.1177/10497323221120501

The voices of stakeholders involved in precision medicine: the co-design and evaluation of qualitative indicators of intervention acceptability, fidelity, and context in PRecISion Medicine for Children with Cancer in Australia

Abstract

Keywords

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Projects

Centre for Research Excellence in Implementation Science in Oncology (CRE-ISO)

NHMRC Partnership Centre on Health System Sustainability

Cite this