TY - JOUR
T1 - The wellbeing neuro course
T2 - a randomised controlled trial of an internet-delivered transdiagnostic psychological intervention for adults with neurological disorders
AU - Gandy, Milena
AU - Heriseanu, Andreea I.
AU - Balakumar, Tanya
AU - Karin, Eyal
AU - Walker, Jennie
AU - Hathway, Taylor
AU - Bisby, Madelyne A.
AU - Scott, Amelia J.
AU - Dudeney, Joanne
AU - Fisher, Alana
AU - Titov, Nickolai
AU - Dear, Blake F.
N1 - Copyright the Author(s) 2023. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.
PY - 2023/10
Y1 - 2023/10
N2 - Background Mental health and functional difficulties are highly comorbid across neurological disorders, but supportive care options are limited. This randomised controlled trial assessed the efficacy of a novel transdiagnostic internet-delivered psychological intervention for adults with neurological disorders. Methods 221 participants with a confirmed diagnosis of epilepsy, multiple sclerosis, Parkinson's disease, or an acquired brain injury were allocated to either an immediate treatment group (n = 115) or treatment-as-usual waitlist control (n = 106). The intervention, the Wellbeing Neuro Course, was delivered online via the eCentreClinic website. The Course includes six lessons, based on cognitive behavioural therapy, delivered over 10 weeks with support from a psychologist via email and telephone. Primary outcomes were symptoms of depression (PHQ-9), anxiety (GAD-7) and disability (WHODAS 2.0). Results 215 participants commenced the trial (treatment n = 111; control n = 104) and were included in intention-to-treat analysis. At post-treatment, we observed significant between-group differences in depression (PHQ-9; difference = 3.07 [95% CI 2.04-4.11], g = 0.62), anxiety (GAD-7; difference = 1.87 [0.92-2.81], g = 0.41) and disability (WHODAS 2.0 difference = 3.08 [1.09-5.06], g = 0.31), that favoured treatment (all ps < 0.001). Treatment-related effects were maintained at 3-month follow-up. Findings were achieved with minimal clinician time (average of 95.7 min [s.d. = 59.3] per participant), highlighting the public health potential of this approach to care. No adverse treatment events were reported. Conclusions Internet-delivered psychological interventions could be a suitable model of accessible supportive care for patients with neurological disorders.
AB - Background Mental health and functional difficulties are highly comorbid across neurological disorders, but supportive care options are limited. This randomised controlled trial assessed the efficacy of a novel transdiagnostic internet-delivered psychological intervention for adults with neurological disorders. Methods 221 participants with a confirmed diagnosis of epilepsy, multiple sclerosis, Parkinson's disease, or an acquired brain injury were allocated to either an immediate treatment group (n = 115) or treatment-as-usual waitlist control (n = 106). The intervention, the Wellbeing Neuro Course, was delivered online via the eCentreClinic website. The Course includes six lessons, based on cognitive behavioural therapy, delivered over 10 weeks with support from a psychologist via email and telephone. Primary outcomes were symptoms of depression (PHQ-9), anxiety (GAD-7) and disability (WHODAS 2.0). Results 215 participants commenced the trial (treatment n = 111; control n = 104) and were included in intention-to-treat analysis. At post-treatment, we observed significant between-group differences in depression (PHQ-9; difference = 3.07 [95% CI 2.04-4.11], g = 0.62), anxiety (GAD-7; difference = 1.87 [0.92-2.81], g = 0.41) and disability (WHODAS 2.0 difference = 3.08 [1.09-5.06], g = 0.31), that favoured treatment (all ps < 0.001). Treatment-related effects were maintained at 3-month follow-up. Findings were achieved with minimal clinician time (average of 95.7 min [s.d. = 59.3] per participant), highlighting the public health potential of this approach to care. No adverse treatment events were reported. Conclusions Internet-delivered psychological interventions could be a suitable model of accessible supportive care for patients with neurological disorders.
KW - anxiety
KW - cognitive behaviour therapy
KW - depression
KW - digital
KW - neurology
KW - psychotherapy
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=mq-pure-production&SrcAuth=WosAPI&KeyUT=WOS:000941850000001&DestLinkType=FullRecord&DestApp=WOS
UR - http://www.scopus.com/inward/record.url?scp=85160982415&partnerID=8YFLogxK
U2 - 10.1017/S0033291723000338
DO - 10.1017/S0033291723000338
M3 - Article
SN - 0033-2917
VL - 53
SP - 6817
EP - 6827
JO - Psychological Medicine
JF - Psychological Medicine
IS - 14
ER -