Theories of etiopathogenesis of breast implant-associated anaplastic large cell lymphoma

Pratik Rastogi, Edward Riordan, David Moon, Anand K. Deva

    Research output: Contribution to journalReview articlepeer-review

    45 Citations (Scopus)

    Abstract

    Breast implant-associated anaplastic large cell lymphoma is a malignancy of T lymphocytes that is associated with the use of textured breast implants in both esthetic and reconstructive surgeries. Patients typically present with a delayed seroma 8-10 years following implantation or-less commonly-with a capsular mass or systemic disease. Current theories on disease pathogenesis focus on the interplay among textured implants, Gram-negative bacteria, host genetics, and time. The possible roles of silicone leachables and particles have been less well substantiated. This review aims to synthesize the existing scientific evidence regarding breast implant-associated anaplastic large cell lymphoma etiopathogenesis.

    Original languageEnglish
    Pages (from-to)23S-29S
    Number of pages7
    JournalPlastic and Reconstructive Surgery
    Volume143
    Issue number3
    DOIs
    Publication statusPublished - 1 Mar 2019

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