Abstract
Objective: To systematically appraise and summarise meta-analyses investigating the effect of exercise compared with a control condition on health outcomes in cancer survivors. Design: Umbrella review of intervention systematic reviews. Data sources: Web of Science, Scopus, Cochrane Library, CINAHL and MEDLINE databases were searched using a predefined search strategy. Eligibility criteria: Eligible meta-analyses compared health outcomes between cancer survivors participating in an exercise intervention and a control condition. Health outcomes were cardiovascular fitness, muscle strength, health-related quality of life, cancer-related fatigue and depression. Pooled effect estimates from each meta-analysis were quantified using standardised mean differences and considered trivial (<0.20), small (0.20-0.49), moderate (0.50-0.79) and large (≥0.80). Findings were summarised using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system. Results: There were 65 eligible articles that reported a total of 140 independent meta-analyses. 139/140 meta-analyses suggested a beneficial effect of exercise. The beneficial effect was statistically significant in 104 (75%) meta-analyses. Most effect sizes were moderate for cardiovascular fitness and muscle strength and small for cancer-related fatigue, health-related quality of life and depression. The quality of evidence was variable according to the GRADE scale, with most studies rated low or moderate quality. Median incidence of exercise-related adverse events was 3.5%. Conclusion: Exercise likely has an important role in helping to manage physical function, mental health, general well-being and quality of life in people undergoing and recovering from cancer and side effects of treatment. PROSPERO registration number: CRD42015020194.
| Language | English |
|---|---|
| Article number | 1311 |
| Pages | 1-11 |
| Number of pages | 11 |
| Journal | British Journal of Sports Medicine |
| Volume | 52 |
| Issue number | 20 |
| Early online date | 16 Mar 2018 |
| DOIs | |
| Publication status | Published - Oct 2018 |
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Keywords
- aerobic fitness
- cancer
- fatigue
- physical activity
- quality of life
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}
Therapeutic effects of aerobic and resistance exercises for cancer survivors : a systematic review of meta-analyses of clinical trials. / Fuller, Joel T.; Hartland, Michael C.; Maloney, Luke T.; Davison, Kade.
In: British Journal of Sports Medicine, Vol. 52, No. 20, 1311, 10.2018, p. 1-11.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Therapeutic effects of aerobic and resistance exercises for cancer survivors
T2 - British Journal of Sports Medicine
AU - Fuller, Joel T.
AU - Hartland, Michael C.
AU - Maloney, Luke T.
AU - Davison, Kade
PY - 2018/10
Y1 - 2018/10
N2 - Objective: To systematically appraise and summarise meta-analyses investigating the effect of exercise compared with a control condition on health outcomes in cancer survivors. Design: Umbrella review of intervention systematic reviews. Data sources: Web of Science, Scopus, Cochrane Library, CINAHL and MEDLINE databases were searched using a predefined search strategy. Eligibility criteria: Eligible meta-analyses compared health outcomes between cancer survivors participating in an exercise intervention and a control condition. Health outcomes were cardiovascular fitness, muscle strength, health-related quality of life, cancer-related fatigue and depression. Pooled effect estimates from each meta-analysis were quantified using standardised mean differences and considered trivial (<0.20), small (0.20-0.49), moderate (0.50-0.79) and large (≥0.80). Findings were summarised using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system. Results: There were 65 eligible articles that reported a total of 140 independent meta-analyses. 139/140 meta-analyses suggested a beneficial effect of exercise. The beneficial effect was statistically significant in 104 (75%) meta-analyses. Most effect sizes were moderate for cardiovascular fitness and muscle strength and small for cancer-related fatigue, health-related quality of life and depression. The quality of evidence was variable according to the GRADE scale, with most studies rated low or moderate quality. Median incidence of exercise-related adverse events was 3.5%. Conclusion: Exercise likely has an important role in helping to manage physical function, mental health, general well-being and quality of life in people undergoing and recovering from cancer and side effects of treatment. PROSPERO registration number: CRD42015020194.
AB - Objective: To systematically appraise and summarise meta-analyses investigating the effect of exercise compared with a control condition on health outcomes in cancer survivors. Design: Umbrella review of intervention systematic reviews. Data sources: Web of Science, Scopus, Cochrane Library, CINAHL and MEDLINE databases were searched using a predefined search strategy. Eligibility criteria: Eligible meta-analyses compared health outcomes between cancer survivors participating in an exercise intervention and a control condition. Health outcomes were cardiovascular fitness, muscle strength, health-related quality of life, cancer-related fatigue and depression. Pooled effect estimates from each meta-analysis were quantified using standardised mean differences and considered trivial (<0.20), small (0.20-0.49), moderate (0.50-0.79) and large (≥0.80). Findings were summarised using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system. Results: There were 65 eligible articles that reported a total of 140 independent meta-analyses. 139/140 meta-analyses suggested a beneficial effect of exercise. The beneficial effect was statistically significant in 104 (75%) meta-analyses. Most effect sizes were moderate for cardiovascular fitness and muscle strength and small for cancer-related fatigue, health-related quality of life and depression. The quality of evidence was variable according to the GRADE scale, with most studies rated low or moderate quality. Median incidence of exercise-related adverse events was 3.5%. Conclusion: Exercise likely has an important role in helping to manage physical function, mental health, general well-being and quality of life in people undergoing and recovering from cancer and side effects of treatment. PROSPERO registration number: CRD42015020194.
KW - aerobic fitness
KW - cancer
KW - fatigue
KW - physical activity
KW - quality of life
UR - http://www.scopus.com/inward/record.url?scp=85049148686&partnerID=8YFLogxK
U2 - 10.1136/bjsports-2017-098285
DO - 10.1136/bjsports-2017-098285
M3 - Article
VL - 52
SP - 1
EP - 11
JO - British Journal of Sports Medicine
JF - British Journal of Sports Medicine
SN - 0306-3674
IS - 20
M1 - 1311
ER -