Therapeutic effects of aerobic and resistance exercises for cancer survivors: a systematic review of meta-analyses of clinical trials

Joel T. Fuller, Michael C. Hartland, Luke T. Maloney, Kade Davison

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Objective: To systematically appraise and summarise meta-analyses investigating the effect of exercise compared with a control condition on health outcomes in cancer survivors. Design: Umbrella review of intervention systematic reviews. Data sources: Web of Science, Scopus, Cochrane Library, CINAHL and MEDLINE databases were searched using a predefined search strategy. Eligibility criteria: Eligible meta-analyses compared health outcomes between cancer survivors participating in an exercise intervention and a control condition. Health outcomes were cardiovascular fitness, muscle strength, health-related quality of life, cancer-related fatigue and depression. Pooled effect estimates from each meta-analysis were quantified using standardised mean differences and considered trivial (<0.20), small (0.20-0.49), moderate (0.50-0.79) and large (≥0.80). Findings were summarised using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system. Results: There were 65 eligible articles that reported a total of 140 independent meta-analyses. 139/140 meta-analyses suggested a beneficial effect of exercise. The beneficial effect was statistically significant in 104 (75%) meta-analyses. Most effect sizes were moderate for cardiovascular fitness and muscle strength and small for cancer-related fatigue, health-related quality of life and depression. The quality of evidence was variable according to the GRADE scale, with most studies rated low or moderate quality. Median incidence of exercise-related adverse events was 3.5%. Conclusion: Exercise likely has an important role in helping to manage physical function, mental health, general well-being and quality of life in people undergoing and recovering from cancer and side effects of treatment. PROSPERO registration number: CRD42015020194.

LanguageEnglish
Article number1311
Pages1-11
Number of pages11
JournalBritish Journal of Sports Medicine
Volume52
Issue number20
Early online date16 Mar 2018
DOIs
Publication statusPublished - Oct 2018

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Therapeutic Uses
Survivors
Meta-Analysis
Clinical Trials
Exercise
Neoplasms
Quality of Life
Muscle Strength
Fatigue
Health
Depression
Information Storage and Retrieval
MEDLINE
Libraries
Mental Health
Databases
Incidence

Keywords

  • aerobic fitness
  • cancer
  • fatigue
  • physical activity
  • quality of life

Cite this

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title = "Therapeutic effects of aerobic and resistance exercises for cancer survivors: a systematic review of meta-analyses of clinical trials",
abstract = "Objective: To systematically appraise and summarise meta-analyses investigating the effect of exercise compared with a control condition on health outcomes in cancer survivors. Design: Umbrella review of intervention systematic reviews. Data sources: Web of Science, Scopus, Cochrane Library, CINAHL and MEDLINE databases were searched using a predefined search strategy. Eligibility criteria: Eligible meta-analyses compared health outcomes between cancer survivors participating in an exercise intervention and a control condition. Health outcomes were cardiovascular fitness, muscle strength, health-related quality of life, cancer-related fatigue and depression. Pooled effect estimates from each meta-analysis were quantified using standardised mean differences and considered trivial (<0.20), small (0.20-0.49), moderate (0.50-0.79) and large (≥0.80). Findings were summarised using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system. Results: There were 65 eligible articles that reported a total of 140 independent meta-analyses. 139/140 meta-analyses suggested a beneficial effect of exercise. The beneficial effect was statistically significant in 104 (75{\%}) meta-analyses. Most effect sizes were moderate for cardiovascular fitness and muscle strength and small for cancer-related fatigue, health-related quality of life and depression. The quality of evidence was variable according to the GRADE scale, with most studies rated low or moderate quality. Median incidence of exercise-related adverse events was 3.5{\%}. Conclusion: Exercise likely has an important role in helping to manage physical function, mental health, general well-being and quality of life in people undergoing and recovering from cancer and side effects of treatment. PROSPERO registration number: CRD42015020194.",
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Therapeutic effects of aerobic and resistance exercises for cancer survivors : a systematic review of meta-analyses of clinical trials. / Fuller, Joel T.; Hartland, Michael C.; Maloney, Luke T.; Davison, Kade.

In: British Journal of Sports Medicine, Vol. 52, No. 20, 1311, 10.2018, p. 1-11.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Therapeutic effects of aerobic and resistance exercises for cancer survivors

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AU - Hartland, Michael C.

AU - Maloney, Luke T.

AU - Davison, Kade

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