Therapeutic opportunities for targeting cold pain pathways

Kathleen Yin, Katharina Zimmermann, Irina Vetter, Richard J. Lewis*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)


Cold pain is a frequent symptom in neuropathic pain. Compared to other pain modalities, such as heat pain, the mechanisms behind physiological and pathological cold pain remain elusive. Moreover, it is becoming increasingly evident that cold pain pharmacology differs between various neuropathic pain conditions, making mechanism-directed treatment based on an understanding of the underlying pathophysiological mechanisms imperative to achieving clinical success. Here we review the processes of physiological and abnormal cold sensing, the pharmacology of cold nociception, cold hyperalgesia and cold allodynia, and provide an overview of cold pain syndromes and their current and potential treatments.

Original languageEnglish
Pages (from-to)125-140
Number of pages16
JournalBiochemical Pharmacology
Issue number2
Publication statusPublished - 15 Jan 2015
Externally publishedYes


  • Cold pain sensitisation
  • Cold pain signalling
  • Ion channels
  • Pain pathways
  • Treatment
  • TRP channels


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