Therapeutic peptides

Lars Ittner; Daryl Ariawan

Therapeutic peptides

Lars Ittner (Inventor), Daryl Ariawan (Inventor)

Research output: Patent

Abstract

The invention relates generally to peptides comprising an amino acid sequence as set forth in SEQ ID NO: 1: CPRILX1, wherein X1 is a chain of 3 or more R residues, and to peptides comprising an amino acid sequence as set forth in SEQ ID NO:2: KLX2X3IESX4X5 wherein: X2, X3 and X4 are any amino acid residue; and X5 is selected from V and I, provided that SEQ ID NO:2 is not KLSSIESDV. The invention further relates to fusion peptides thereof, methods of delivering an active agent across a cell membrane and/or across the blood brain barrier, and methods of treating or preventing a condition associated with neuronal hyperexcitation-associated neurotoxicity.

Original language	English
Patent number	WO2025208177
IPC	C07K 7/ 06 2006.1,A61K 38/00 2006.1,A61P 25/28 2006.1,C07K 14/00 2006.1
Priority date	3/04/24
Filing date	3/04/25
Publication status	Published - 9 Oct 2025

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title = "Therapeutic peptides",

abstract = "The invention relates generally to peptides comprising an amino acid sequence as set forth in SEQ ID NO: 1: CPRILX1, wherein X1 is a chain of 3 or more R residues, and to peptides comprising an amino acid sequence as set forth in SEQ ID NO:2: KLX2X3IESX4X5 wherein: X2, X3 and X4 are any amino acid residue; and X5 is selected from V and I, provided that SEQ ID NO:2 is not KLSSIESDV. The invention further relates to fusion peptides thereof, methods of delivering an active agent across a cell membrane and/or across the blood brain barrier, and methods of treating or preventing a condition associated with neuronal hyperexcitation-associated neurotoxicity.",

author = "Lars Ittner and Daryl Ariawan",

year = "2025",

month = oct,

day = "9",

language = "English",

type = "Patent",

note = "WO2025208177; C07K 7/ 06 2006.1,A61K 38/00 2006.1,A61P 25/28 2006.1,C07K 14/00 2006.1",

}

TY - PAT

T1 - Therapeutic peptides

AU - Ittner, Lars

AU - Ariawan, Daryl

PY - 2025/10/9

Y1 - 2025/10/9

N2 - The invention relates generally to peptides comprising an amino acid sequence as set forth in SEQ ID NO: 1: CPRILX1, wherein X1 is a chain of 3 or more R residues, and to peptides comprising an amino acid sequence as set forth in SEQ ID NO:2: KLX2X3IESX4X5 wherein: X2, X3 and X4 are any amino acid residue; and X5 is selected from V and I, provided that SEQ ID NO:2 is not KLSSIESDV. The invention further relates to fusion peptides thereof, methods of delivering an active agent across a cell membrane and/or across the blood brain barrier, and methods of treating or preventing a condition associated with neuronal hyperexcitation-associated neurotoxicity.

AB - The invention relates generally to peptides comprising an amino acid sequence as set forth in SEQ ID NO: 1: CPRILX1, wherein X1 is a chain of 3 or more R residues, and to peptides comprising an amino acid sequence as set forth in SEQ ID NO:2: KLX2X3IESX4X5 wherein: X2, X3 and X4 are any amino acid residue; and X5 is selected from V and I, provided that SEQ ID NO:2 is not KLSSIESDV. The invention further relates to fusion peptides thereof, methods of delivering an active agent across a cell membrane and/or across the blood brain barrier, and methods of treating or preventing a condition associated with neuronal hyperexcitation-associated neurotoxicity.

M3 - Patent

M1 - WO2025208177

Y2 - 2025/04/03

ER -

Therapeutic peptides

Abstract

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