Therapeutic relevance of ozone therapy in degenerative diseases: focus on diabetes and spinal pain

Nady Braidy*, Morteza Izadi, Antoni Sureda, Nematollah Jonaidi-Jafari, Abdolali Banki, Seyed F. Nabavi, Seyed M. Nabavi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

Ozone, one of the most important air pollutants, is a triatomic molecule containing three atoms of oxygen that results in an unstable form due to its mesomeric structure. It has been well-known that ozone has potent ability to oxidize organic compounds and can induce respiratory irritation. Although ozone has deleterious effects, many therapeutic effects have also been suggested. Since last few decades, the therapeutic potential of ozone has gained much attention through its strong capacity to induce controlled and moderated oxidative stress when administered in precise therapeutic doses. A plethora of scientific evidence showed that the activation of hypoxia inducible factor-1α (HIF-1a), nuclear factor of activated T-cells (NFAT), nuclear factor-erythroid 2-related factor 2-antioxidant response element (Nrf2-ARE), and activated protein-1 (AP-1) pathways are the main molecular mechanisms underlying the therapeutic effects of ozone therapy. Activation of these molecular pathways leads to up-regulation of endogenous antioxidant systems, activation of immune functions as well as suppression of inflammatory processes, which is important for correcting oxidative stress in diabetes and spinal pain. The present study intended to review critically the available scientific evidence concerning the beneficial properties of ozone therapy for treatment of diabetic complications and spinal pain. It finds benefit for integrating the therapy with ozone into pharmacological procedures, instead of a substitutive or additional option to therapy.

Original languageEnglish
Pages (from-to)2705-2714
Number of pages10
JournalJournal of Cellular Physiology
Volume233
Issue number4
DOIs
Publication statusPublished - Apr 2018
Externally publishedYes

Keywords

  • Diabetes
  • Oxidative stress
  • Ozone
  • Spinal pain

Fingerprint

Dive into the research topics of 'Therapeutic relevance of ozone therapy in degenerative diseases: focus on diabetes and spinal pain'. Together they form a unique fingerprint.

Cite this