Therapeutic role of sirtuins in neurodegenerative disease and their modulation by polyphenols

Searching for effective therapeutic agents‏‎ to ‎‏prevent‏ ‏neurodegeneration ‎is a challenging task due ‎to ‎the growing list of neurodegenerative disorders associated with a multitude of inter-related pathways.‎ The induction and inhibition of several different signaling pathways has been shown to slow down and/or attenuate ‎neurodegeneration and decline in cognition and locomotor function. Among these signaling pathways, a new class of enzymes known as sirtuins or silent information regulators of gene transcription has been shown to play important regulatory roles in the ageing process. SIRT1, a nuclear sirtuin, has received ‎particular interest due to its role as a deacetylase for several metabolic and signaling proteins involved in stress response, apoptosis, mitochondrial function, self-renewal, and ‎neuroprotection. ‎A new strategy to treat ‎neurodegenerative diseases is targeted therapy. In ‎this ‎paper, we‎ ‎ reviewed up-to-date findings regarding the targeting of ‎SIRT1 by polyphenolic ‎compounds,‎ ‎as a ‎new ‎‏approach in the search for novel, safe and effective treatments for ‎ ‎neurodegenerative ‎diseases. ‎