THERE ARE FEW CATECHOLAMINE‐ OR NEUROPEPTIDE Y‐CONTAINING SYNAPSES IN THE INTERMEDIOLATERAL CELL COLUMN OF RAT THORACIC SPINAL CORD

Ida J. Llewellyn‐Smith*, Jane B. Minson, Paul M. Pilowsky, John P. Chalmers

*Corresponding author for this work

    Research output: Contribution to journalArticle

    14 Citations (Scopus)

    Abstract

    1. A quantitative electron microscopic immunocytochemical technique was used to assess the number of synapses immunoreactive for tyrosine hydroxylase (TH), phenylethanolamine N‐methyltransferase (PNMT) and neuropeptide Y (NPY) in the intermediolateral cell column in segments T2 and T3 of rat thoracic spinal cord. 2. TH synapses comprised about 5%; PNMT synapses 1–2%; and NPY synapses 1–2% of the total number of synapses in the intermediolateral cell column. All three types of synapses were predominantly or exclusively on dendrites. 3. Our results suggest that catecholamine/NPY neurons may not provide a major synaptic input to sympathetic preganglionic neurons in rat upper thoracic spinal cord.

    Original languageEnglish
    Pages (from-to)111-115
    Number of pages5
    JournalClinical and Experimental Pharmacology and Physiology
    Volume18
    Issue number2
    DOIs
    Publication statusPublished - 1991

    Keywords

    • immunocytochemistry
    • neuropeptide Y
    • phenylethanolamine N‐methyltransferase
    • sympathetic preganglionic neurons
    • tyrosine hydroxylase
    • ultrastructure.

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