Thiosemicarbazones from the old to new: iron chelators that are more than just ribonucleotide reductase inhibitors

Yu Yu, Danuta S. Kalinowski, Zaklina Kovacevic, Aritee R. Siafakas, Patric J. Jansson, Christian Stefani, David B. Lovejoy, Philip C. Sharpe, Paul V. Bernhardt, Des R. Richardson*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

287 Citations (Scopus)
Original languageEnglish
Pages (from-to)5271-5294
Number of pages24
JournalJournal of Medicinal Chemistry
Volume52
Issue number17
DOIs
Publication statusPublished - 10 Sep 2009
Externally publishedYes

Keywords

  • PYRIDOXAL ISONICOTINOYL HYDRAZONE
  • EFFECTIVE ANTIPROLIFERATIVE AGENTS
  • METASTASIS SUPPRESSOR GENE
  • ALPHA-(N)-HETEROCYCLIC CARBOXALDEHYDE THIOSEMICARBAZONES
  • DIVALENT METAL TRANSPORTER-1
  • SELECTIVE ANTITUMOR-ACTIVITY
  • INTRACELLULAR LABILE IRON
  • CELL-CYCLE PROGRESSION
  • ANTI-MALARIAL AGENTS
  • BREAST-CANCER CELLS

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