Three-dimensional luminescence tomographic visualization of biological tissues

V. V. Rocheva, A. G. Savelyev*, A. V. Nechaev, A. N. Generalova, V. A. Semchishen, A. V. Zvyagin, E. V. Khaydukov

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    2 Citations (Scopus)

    Abstract

    We propose a method for obtaining a fluorescence tomographic image for visualization and diagnosis of tissues of a living organism. The method is based on the excitation of the luminescence of multicolor upconverting nanoparticles localized in the depth of the biological tissue or a phantom imitating it by IR light. By recording the changes in the shape of the spectrum of the intensity of luminescence radiation from luminescent nanoparticles on the surface of the tissue, it is possible to obtain information about the depth of their occurrence. To implement this approach, upconverting nanoparticles were synthesized on the base of β-NaYF4 crystal matrix doped with rare-earth elements Yb3+, Er3+, and Tm3+. The luminescence spectra of the produced nanoparticles upon excitation at a wavelength of 980 nm contain three narrow bands with maxima at wavelengths 540, 655, and 800 nm.

    Original languageEnglish
    Pages (from-to)92-94
    Number of pages3
    JournalOptics and Spectroscopy
    Volume126
    Issue number1
    DOIs
    Publication statusPublished - 1 Jan 2019

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