Timing of administration: for commonly-prescribed medicines in Australia

Gagandeep Kaur*, Craig L. Phillips, Keith Wong, Andrew J. McLachlan, Bandana Saini

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

19 Citations (Scopus)
10 Downloads (Pure)

Abstract

Chronotherapy involves the administration of medication in coordination with the body’s circadian rhythms to maximise therapeutic effectiveness and minimise/avoid adverse effects. The aim of this study is to investigate the “time of administration” recommendations on chronotherapy for commonly-prescribed medicines in Australia. This study also aimed to explore the quality of information on the timing of administration presented in drug information sources, such as consumer medicine information (CMI) and approved product information (PI). Databases were searched for original research studies reporting on the impact of “time of administration” of the 30 most commonly-prescribed medicines in Australia for 2014. Further, time of administration recommendations from drug information sources were compared to the evidence from chronotherapy trials. Our search revealed 27 research studies, matching the inclusion and exclusion criteria. In 56% (n = 15) of the research studies, the therapeutic effect of the medicine varied with the time of administration, i.e., supported chronotherapy. For some medicines (e.g., simvastatin), circadian-based optimal administration time was evident in the information sources. Overall, dedicated studies on the timing of administration of medicines are sparse, and more studies are required. As it stands, information provision to consumers and health professionals about the optimal “time” to take medications lags behind emerging evidence.

Original languageEnglish
Article number13
Pages (from-to)1-18
Number of pages18
JournalPharmaceutics
Volume8
Issue number2
DOIs
Publication statusPublished - 15 Apr 2016
Externally publishedYes

Bibliographical note

Copyright the Author(s) 2016. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • Antihypertensives
  • Australia
  • Chronotherapy
  • Circadian rhythm
  • Medicines
  • Proton pump inhibitors
  • Statins
  • Timing of drug administration

Fingerprint

Dive into the research topics of 'Timing of administration: for commonly-prescribed medicines in Australia'. Together they form a unique fingerprint.

Cite this