Toolboxes for a standardised and systematic study of glycans

Matthew P. Campbell, René Ranzinger, Thomas Lütteke, Julien Mariethoz, Catherine A. Hayes, Jingyu Zhang, Yukie Akune, Kiyoko F. Aoki-Kinoshita, David Damerell, Giorgio Carta, Will S. York, Stuart M. Haslam, Hisashi Narimatsu, Pauline M. Rudd, Niclas G. Karlsson, Nicolle H. Packer, Frédérique Lisacek*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

48 Citations (Scopus)
64 Downloads (Pure)

Abstract

Background: Recent progress in method development for characterising the branched structures of complex carbohydrates has now enabled higher throughput technology. Automation of structure analysis then calls for software development since adding meaning to large data collections in reasonable time requires corresponding bioinformatics methods and tools. Current glycobioinformatics resources do cover information on the structure and function of glycans, their interaction with proteins or their enzymatic synthesis. However, this information is partial, scattered and often difficult to find to for non-glycobiologists. Methods: Following our diagnosis of the causes of the slow development of glycobioinformatics, we review the "objective" difficulties encountered in defining adequate formats for representing complex entities and developing efficient analysis software. Results: Various solutions already implemented and strategies defined to bridge glycobiology with different fields and integrate the heterogeneous glyco-related information are presented. Conclusions: Despite the initial stage of our integrative efforts, this paper highlights the rapid expansion of glycomics, the validity of existing resources and the bright future of glycobioinformatics.

Original languageEnglish
Article numberS9
Pages (from-to)1-11
Number of pages11
JournalBMC Bioinformatics
Volume15
Issue numberS1
DOIs
Publication statusPublished - 10 Jan 2014

Bibliographical note

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