Tools to study individual genes and proteins

Ulf Landegren*, Johan Banér, Fredrik Dahl, Jenny Göransson, Mats Gullberg, Sigrun Gustafsdottir, Sara Henriksson, Mathias Howell, Jonas Jarvius, Malin Jarvius, Henrik Johansson, Masood Kamali, Chatarina Larsson, Karl Johan Leuchowius, Jonas Melin, Fredrik Nikolajeff, Mats Nilsson, Edith Schallmeiner, Ola Söderberg, Johan Stenberg

*Corresponding author for this work

    Research output: Chapter in Book/Report/Conference proceedingConference proceeding contributionpeer-review

    Abstract

    A family of molecular tools will be described that taken together allow complex biological samples to be interrogated for large sets of target nucleic acid or protein molecules, extending down to even individual molecules. We have used the probes for single-molecule detection and counting in microscopic preparations and in microfabricated fluidic channels.

    Original languageEnglish
    Title of host publicationMicro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences
    PublisherTransducer Research Foundation
    Pages1057-1059
    Number of pages3
    Volume1
    ISBN (Print)0974361119, 9780974361116
    Publication statusPublished - 2005
    Event9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005 - Boston, MA, United States
    Duration: 9 Oct 200513 Oct 2005

    Other

    Other9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005
    Country/TerritoryUnited States
    CityBoston, MA
    Period9/10/0513/10/05

    Keywords

    • DNA microarrays
    • High-throughput genomics
    • Microfluidics
    • Molecular diagnostics
    • Molecular tools
    • Padlock probes
    • Proximity ligation
    • Rolling-circle amplification
    • Single-molecule detection

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