Abstract
A family of molecular tools will be described that taken together allow complex biological samples to be interrogated for large sets of target nucleic acid or protein molecules, extending down to even individual molecules. We have used the probes for single-molecule detection and counting in microscopic preparations and in microfabricated fluidic channels.
Original language | English |
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Title of host publication | Micro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences |
Publisher | Transducer Research Foundation |
Pages | 1057-1059 |
Number of pages | 3 |
Volume | 1 |
ISBN (Print) | 0974361119, 9780974361116 |
Publication status | Published - 2005 |
Event | 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005 - Boston, MA, United States Duration: 9 Oct 2005 → 13 Oct 2005 |
Other
Other | 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005 |
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Country/Territory | United States |
City | Boston, MA |
Period | 9/10/05 → 13/10/05 |
Keywords
- DNA microarrays
- High-throughput genomics
- Microfluidics
- Molecular diagnostics
- Molecular tools
- Padlock probes
- Proximity ligation
- Rolling-circle amplification
- Single-molecule detection